Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100889992> ?p ?o ?g. }
- W3100889992 endingPage "1430" @default.
- W3100889992 startingPage "1418" @default.
- W3100889992 abstract "The chronic mild stress (CMS) procedure is a widely used animal model of depression, and its application in Wistar-Kyoto (WKY) rats has been validated as a model of antidepressant-refractory depression. While not responding to chronic treatment with antidepressant drugs, WKY rats do respond to acute deep brain stimulation (DBS) of the medial prefrontal cortex (mPFC). In antidepressant-responsive strains there is evidence suggesting a role for AMPA subtype of glutamate receptor in the action mechanism of both antidepressants and DBS.Animals were subjected to CMS for 6 to 8 weeks; sucrose intake was monitored weekly and novel object recognition (NOR) test was conducted following recovery from CMS. Wistars were treated chronically with venlafaxine (VEN), while WKY were treated acutely with either DBS, optogenetic stimulation (OGS) of virally-transduced (AAV5-hSyn-ChR2-EYFP) mPFC or ventral hippocampus, or acute intra-mPFC injection of the AMPA receptor positive allosteric modulator CX-516. The AMPA receptor antagonist NBQX was administered, at identical sites in mPFC, immediately following the exposure trial in the NOR.Sucrose intake and NOR were suppressed by CMS, and restored by VEN in Wistars and by DBS, OGS, or CX-516 in WKY. However, OGS of the ventral hippocampal afferents to mPFC was ineffective. A low dose of NBQX selectively blocked the procognitive effect of VEN, DBS and OGS.These results suggest that activation of AMPA receptors in the mPFC represents a common pathway for the antidepressant effects of both conventional (VEN) and novel (DBS, OGS) antidepressant modalities, in both antidepressant responsive (Wistar) and antidepressant-resistant (WKY) rats." @default.
- W3100889992 created "2020-11-23" @default.
- W3100889992 creator A5017203739 @default.
- W3100889992 creator A5017508276 @default.
- W3100889992 creator A5035324088 @default.
- W3100889992 creator A5047477789 @default.
- W3100889992 creator A5061886376 @default.
- W3100889992 creator A5072319767 @default.
- W3100889992 date "2020-11-17" @default.
- W3100889992 modified "2023-09-26" @default.
- W3100889992 title "AMPA receptors mediate the pro-cognitive effects of electrical and optogenetic stimulation of the medial prefrontal cortex in antidepressant non-responsive Wistar–Kyoto rats" @default.
- W3100889992 cites W1568270351 @default.
- W3100889992 cites W1812482953 @default.
- W3100889992 cites W1895515176 @default.
- W3100889992 cites W1920706374 @default.
- W3100889992 cites W1942655249 @default.
- W3100889992 cites W1945290573 @default.
- W3100889992 cites W1965965542 @default.
- W3100889992 cites W1966449086 @default.
- W3100889992 cites W1971520303 @default.
- W3100889992 cites W1977430165 @default.
- W3100889992 cites W1978235424 @default.
- W3100889992 cites W1978926207 @default.
- W3100889992 cites W1980620165 @default.
- W3100889992 cites W1982002064 @default.
- W3100889992 cites W2003443050 @default.
- W3100889992 cites W2004118951 @default.
- W3100889992 cites W2009309964 @default.
- W3100889992 cites W2010167850 @default.
- W3100889992 cites W2012910730 @default.
- W3100889992 cites W2018378637 @default.
- W3100889992 cites W2023081218 @default.
- W3100889992 cites W2025204726 @default.
- W3100889992 cites W2032463021 @default.
- W3100889992 cites W2032739515 @default.
- W3100889992 cites W2034006349 @default.
- W3100889992 cites W2035741946 @default.
- W3100889992 cites W2036699165 @default.
- W3100889992 cites W2042129379 @default.
- W3100889992 cites W2043220571 @default.
- W3100889992 cites W2044069216 @default.
- W3100889992 cites W2045595011 @default.
- W3100889992 cites W2046140176 @default.
- W3100889992 cites W2046985909 @default.
- W3100889992 cites W2055096975 @default.
- W3100889992 cites W2055347004 @default.
- W3100889992 cites W2060835688 @default.
- W3100889992 cites W2065427765 @default.
- W3100889992 cites W2066347174 @default.
- W3100889992 cites W2070005343 @default.
- W3100889992 cites W2072441360 @default.
- W3100889992 cites W2077830856 @default.
- W3100889992 cites W2078569879 @default.
- W3100889992 cites W2080458393 @default.
- W3100889992 cites W2080640632 @default.
- W3100889992 cites W2088396693 @default.
- W3100889992 cites W2094297227 @default.
- W3100889992 cites W2097716576 @default.
- W3100889992 cites W2100346695 @default.
- W3100889992 cites W2103255996 @default.
- W3100889992 cites W2103993985 @default.
- W3100889992 cites W2109334244 @default.
- W3100889992 cites W2129411932 @default.
- W3100889992 cites W2130136912 @default.
- W3100889992 cites W2136228108 @default.
- W3100889992 cites W2142002093 @default.
- W3100889992 cites W2150071717 @default.
- W3100889992 cites W2157450506 @default.
- W3100889992 cites W2160369817 @default.
- W3100889992 cites W2171340584 @default.
- W3100889992 cites W2171752682 @default.
- W3100889992 cites W2206080083 @default.
- W3100889992 cites W2221048720 @default.
- W3100889992 cites W2231648340 @default.
- W3100889992 cites W2237323680 @default.
- W3100889992 cites W2266819934 @default.
- W3100889992 cites W2269173100 @default.
- W3100889992 cites W2306738361 @default.
- W3100889992 cites W2308904057 @default.
- W3100889992 cites W2320297780 @default.
- W3100889992 cites W2339105896 @default.
- W3100889992 cites W2345524922 @default.
- W3100889992 cites W2510666910 @default.
- W3100889992 cites W2616931289 @default.
- W3100889992 cites W2628731659 @default.
- W3100889992 cites W2772436534 @default.
- W3100889992 cites W2810330189 @default.
- W3100889992 cites W2892343289 @default.
- W3100889992 cites W2893284231 @default.
- W3100889992 cites W2894239392 @default.
- W3100889992 cites W2895358400 @default.
- W3100889992 cites W2900937351 @default.
- W3100889992 cites W2903459661 @default.
- W3100889992 cites W2904597631 @default.
- W3100889992 cites W2909539449 @default.
- W3100889992 cites W2917850131 @default.
- W3100889992 cites W2934225719 @default.
- W3100889992 cites W2943332100 @default.