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• W3100897235 abstract "We measured the minimum inhibitory concentration (MIC) of the antimicrobial peptide pexiganan acting on Escherichia coli Escherichia coli , and found an intrinsic variability in such measurements. These results led to a detailed study of the effect of pexiganan on the growth curve of E. coli, using a plate reader and manual plating (i.e. time-kill curves). The measured growth curves, together with single-cell observations and peptide depletion assays, suggested that addition of a sub-MIC concentration of pexiganan to a population of this bacterium killed a fraction of the cells, reducing peptide activity during the process, while leaving the remaining cells unaffected. This pharmacodynamic hypothesis suggests a considerable inoculum effect, which we quantified. Our results cast doubt on the use of the MIC as ‘a measure of the concentration needed for peptide action’ and show how ‘coarse-grained’ studies at the population level give vital information for the correct planning and interpretation of MIC measurements." @default.
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• W3100897235 date "2016-01-01" @default.
• W3100897235 modified "2023-10-16" @default.
• W3100897235 title "What Is the ‘Minimum Inhibitory Concentration’ (MIC) of Pexiganan Acting on Escherichia coli?—A Cautionary Case Study" @default.
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• W3100897235 doi "https://doi.org/10.1007/978-3-319-32189-9_4" @default.
• W3100897235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27193536" @default.
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