Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100898025> ?p ?o ?g. }
- W3100898025 endingPage "12325" @default.
- W3100898025 startingPage "12310" @default.
- W3100898025 abstract "Abstract The Mtq2-Trm112 methyltransferase modifies the eukaryotic translation termination factor eRF1 on the glutamine side chain of a universally conserved GGQ motif that is essential for release of newly synthesized peptides. Although this modification is found in the three domains of life, its exact role in eukaryotes remains unknown. As the deletion of MTQ2 leads to severe growth impairment in yeast, we have investigated its role further and tested its putative involvement in ribosome biogenesis. We found that Mtq2 is associated with nuclear 60S subunit precursors, and we demonstrate that its catalytic activity is required for nucleolar release of pre-60S and for efficient production of mature 5.8S and 25S rRNAs. Thus, we identify Mtq2 as a novel ribosome assembly factor important for large ribosomal subunit formation. We propose that Mtq2-Trm112 might modify eRF1 in the nucleus as part of a quality control mechanism aimed at proof-reading the peptidyl transferase center, where it will subsequently bind during translation termination." @default.
- W3100898025 created "2020-11-23" @default.
- W3100898025 creator A5010022024 @default.
- W3100898025 creator A5012197467 @default.
- W3100898025 creator A5020837580 @default.
- W3100898025 creator A5025797001 @default.
- W3100898025 creator A5031678955 @default.
- W3100898025 creator A5032936992 @default.
- W3100898025 creator A5043771133 @default.
- W3100898025 creator A5079658433 @default.
- W3100898025 creator A5083727378 @default.
- W3100898025 creator A5084679775 @default.
- W3100898025 date "2020-11-09" @default.
- W3100898025 modified "2023-10-17" @default.
- W3100898025 title "The catalytic activity of the translation termination factor methyltransferase Mtq2-Trm112 complex is required for large ribosomal subunit biogenesis" @default.
- W3100898025 cites W1565814207 @default.
- W3100898025 cites W1963597574 @default.
- W3100898025 cites W1966072209 @default.
- W3100898025 cites W1972721128 @default.
- W3100898025 cites W1975749924 @default.
- W3100898025 cites W1976337128 @default.
- W3100898025 cites W1978080544 @default.
- W3100898025 cites W1979087404 @default.
- W3100898025 cites W1984226589 @default.
- W3100898025 cites W1990203942 @default.
- W3100898025 cites W1995511900 @default.
- W3100898025 cites W2011845273 @default.
- W3100898025 cites W2013947447 @default.
- W3100898025 cites W2015586964 @default.
- W3100898025 cites W2029130204 @default.
- W3100898025 cites W2037973887 @default.
- W3100898025 cites W2041157094 @default.
- W3100898025 cites W2041837525 @default.
- W3100898025 cites W2048903083 @default.
- W3100898025 cites W2055360325 @default.
- W3100898025 cites W2062863411 @default.
- W3100898025 cites W2064846679 @default.
- W3100898025 cites W2074722040 @default.
- W3100898025 cites W2075047101 @default.
- W3100898025 cites W2085304602 @default.
- W3100898025 cites W2087050697 @default.
- W3100898025 cites W2089136281 @default.
- W3100898025 cites W2091955737 @default.
- W3100898025 cites W2093683538 @default.
- W3100898025 cites W2094981306 @default.
- W3100898025 cites W2099126195 @default.
- W3100898025 cites W2099167511 @default.
- W3100898025 cites W2099918563 @default.
- W3100898025 cites W2106403358 @default.
- W3100898025 cites W2108659410 @default.
- W3100898025 cites W2114433875 @default.
- W3100898025 cites W2116471939 @default.
- W3100898025 cites W2117466809 @default.
- W3100898025 cites W2121956597 @default.
- W3100898025 cites W2123704399 @default.
- W3100898025 cites W2129020678 @default.
- W3100898025 cites W2131796353 @default.
- W3100898025 cites W2136953077 @default.
- W3100898025 cites W2138011225 @default.
- W3100898025 cites W2141528669 @default.
- W3100898025 cites W2145810780 @default.
- W3100898025 cites W2149426175 @default.
- W3100898025 cites W2149676146 @default.
- W3100898025 cites W2150802740 @default.
- W3100898025 cites W2157270182 @default.
- W3100898025 cites W2165374873 @default.
- W3100898025 cites W2167784579 @default.
- W3100898025 cites W2169588346 @default.
- W3100898025 cites W2170546657 @default.
- W3100898025 cites W2171792346 @default.
- W3100898025 cites W2185043098 @default.
- W3100898025 cites W2226203144 @default.
- W3100898025 cites W2244705281 @default.
- W3100898025 cites W2282853073 @default.
- W3100898025 cites W2290890274 @default.
- W3100898025 cites W2434565902 @default.
- W3100898025 cites W2508652771 @default.
- W3100898025 cites W2509320946 @default.
- W3100898025 cites W2536231941 @default.
- W3100898025 cites W2537132940 @default.
- W3100898025 cites W2557904026 @default.
- W3100898025 cites W2568612196 @default.
- W3100898025 cites W2582266887 @default.
- W3100898025 cites W2753467283 @default.
- W3100898025 cites W2770436140 @default.
- W3100898025 cites W2774536896 @default.
- W3100898025 cites W2775096538 @default.
- W3100898025 cites W2788198022 @default.
- W3100898025 cites W2793021023 @default.
- W3100898025 cites W2794358105 @default.
- W3100898025 cites W2802476942 @default.
- W3100898025 cites W2884309310 @default.
- W3100898025 cites W2901941802 @default.
- W3100898025 cites W2905406395 @default.
- W3100898025 cites W2921518623 @default.
- W3100898025 cites W2942552883 @default.
- W3100898025 cites W2959601695 @default.
- W3100898025 cites W4242455186 @default.