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- W3100901760 abstract "Abstract Background/Aims: The gastric mucosa responds to hypertonic NaCl by significantly decreasing acid secretion. This study examined the role of nitric oxide in this phenomenon. Methods: A rat stomach was mounted in an ex vivo chamber and perfused with saline; then the potential difference (PD), pH, and acid and/or alkaline responses were measured before and after the application of 1 mol/L NaCl with or without pretreatment with N G -nitro-l-arginine methyl ester (l-NAME), an inhibitor of NO biosynthesis. Results: A dose of 1 mol/L NaCl caused a reduction in PD, a decrease in basal and histamine-stimulated acid secretion, and an increase in luminal HCO 3 - . Prior administration of l-NAME did not affect either the PD or the HCO 3 - response but significantly attenuated the inhibitory effect of 1 mol/ L NaCl on acid secretion. This effect of l-NAME was antagonized by the simultaneous administration with l-arginine but not d-arginine. Histamine-stimulated acid secretion in the normal stomach was significantly reduced by the exogenous NO donor nitroprusside but not by l-NAME. Conclusions: NO is involved in the mechanism of the gastric alkaline response after damage with 1 mol/L NaCl. Irritation of the gastric mucosa by hypertonic NaCl may release endogenous NO, which in turn inhibits acid secretion and unmasks luminal alkalinization caused by HCO 3 - flux in the damaged portion." @default.
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- W3100901760 date "1994-01-01" @default.
- W3100901760 modified "2023-09-23" @default.
- W3100901760 title "Endogenous nitric oxide in gastric alkaline response in the rat stomach after damage." @default.
- W3100901760 doi "https://doi.org/10.1016/s0021-5198(19)49997-6" @default.
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