Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100930159> ?p ?o ?g. }
- W3100930159 abstract "Abstract Opioid abuse has devastating effects on patients, their families, and society. Withdrawal symptoms are severely unpleasant, prolonged, and frequently hinder recovery or lead to relapse. The sharp increase in abuse and overdoses arising from the illicit use of potent and rapidly-acting synthetic opioids, such as fentanyl, highlights the urgency of understanding the withdrawal mechanisms related to these drugs. Progress is impeded by inconsistent reports on opioid withdrawal in different preclinical models. Here, using rats and mice of both sexes, we quantified withdrawal behaviors during spontaneous and naloxone-precipitated withdrawal, following two weeks of intermittent fentanyl exposure. We found that both mice and rats lost weight during exposure and showed increased signs of distress during spontaneous and naloxone precipitated withdrawal. However, these species differed in their expression of withdrawal associated pain, a key contributor to relapse in humans. Spontaneous or ongoing pain was preferentially expressed in rats in both withdrawal conditions, while no change was observed in mice. In contrast, withdrawal associated thermal hyperalgesia was found only in mice. These data suggest that rats and mice diverge in how they experience withdrawal and which aspects of the human condition they most accurately model. These differences highlight each species’ strengths as model systems and can inform experimental design in studies of opioid withdrawal." @default.
- W3100930159 created "2020-11-23" @default.
- W3100930159 creator A5007663058 @default.
- W3100930159 creator A5020531674 @default.
- W3100930159 creator A5030307025 @default.
- W3100930159 creator A5033940436 @default.
- W3100930159 creator A5049876579 @default.
- W3100930159 creator A5078012500 @default.
- W3100930159 date "2020-11-16" @default.
- W3100930159 modified "2023-10-17" @default.
- W3100930159 title "Divergent profiles of fentanyl withdrawal and associated pain in mice and rats" @default.
- W3100930159 cites W1531160152 @default.
- W3100930159 cites W1968651827 @default.
- W3100930159 cites W1969764242 @default.
- W3100930159 cites W1972415537 @default.
- W3100930159 cites W1973194313 @default.
- W3100930159 cites W1977190191 @default.
- W3100930159 cites W1980781066 @default.
- W3100930159 cites W1984902110 @default.
- W3100930159 cites W1985082623 @default.
- W3100930159 cites W1985427696 @default.
- W3100930159 cites W1985659061 @default.
- W3100930159 cites W1988125188 @default.
- W3100930159 cites W1997936944 @default.
- W3100930159 cites W2001960231 @default.
- W3100930159 cites W2002198894 @default.
- W3100930159 cites W2008496364 @default.
- W3100930159 cites W2010605687 @default.
- W3100930159 cites W2014793146 @default.
- W3100930159 cites W2017357698 @default.
- W3100930159 cites W2018914766 @default.
- W3100930159 cites W2020098484 @default.
- W3100930159 cites W2023035230 @default.
- W3100930159 cites W2023430332 @default.
- W3100930159 cites W2024238924 @default.
- W3100930159 cites W2030383594 @default.
- W3100930159 cites W2034632914 @default.
- W3100930159 cites W2040668587 @default.
- W3100930159 cites W2041557338 @default.
- W3100930159 cites W2043313879 @default.
- W3100930159 cites W2044676961 @default.
- W3100930159 cites W2044963578 @default.
- W3100930159 cites W2045218508 @default.
- W3100930159 cites W2047866642 @default.
- W3100930159 cites W2048538659 @default.
- W3100930159 cites W2059024518 @default.
- W3100930159 cites W2061284421 @default.
- W3100930159 cites W2061314535 @default.
- W3100930159 cites W2063166130 @default.
- W3100930159 cites W2065207718 @default.
- W3100930159 cites W2066724335 @default.
- W3100930159 cites W2074010882 @default.
- W3100930159 cites W2083987774 @default.
- W3100930159 cites W2084793623 @default.
- W3100930159 cites W2094267095 @default.
- W3100930159 cites W2097354530 @default.
- W3100930159 cites W2105738918 @default.
- W3100930159 cites W2113408846 @default.
- W3100930159 cites W2116805033 @default.
- W3100930159 cites W2117665610 @default.
- W3100930159 cites W2123562126 @default.
- W3100930159 cites W2126041445 @default.
- W3100930159 cites W2127282142 @default.
- W3100930159 cites W2137516955 @default.
- W3100930159 cites W2139833086 @default.
- W3100930159 cites W2142607990 @default.
- W3100930159 cites W2143179572 @default.
- W3100930159 cites W2152179548 @default.
- W3100930159 cites W2165542532 @default.
- W3100930159 cites W2237792460 @default.
- W3100930159 cites W2319327500 @default.
- W3100930159 cites W2735187631 @default.
- W3100930159 cites W2746574961 @default.
- W3100930159 cites W2753084136 @default.
- W3100930159 cites W2762128566 @default.
- W3100930159 cites W2766740763 @default.
- W3100930159 cites W2794354368 @default.
- W3100930159 cites W2922068945 @default.
- W3100930159 cites W2942361078 @default.
- W3100930159 cites W4237635696 @default.
- W3100930159 cites W4256227861 @default.
- W3100930159 doi "https://doi.org/10.1101/2020.11.16.384818" @default.
- W3100930159 hasPublicationYear "2020" @default.
- W3100930159 type Work @default.
- W3100930159 sameAs 3100930159 @default.
- W3100930159 citedByCount "0" @default.
- W3100930159 crossrefType "posted-content" @default.
- W3100930159 hasAuthorship W3100930159A5007663058 @default.
- W3100930159 hasAuthorship W3100930159A5020531674 @default.
- W3100930159 hasAuthorship W3100930159A5030307025 @default.
- W3100930159 hasAuthorship W3100930159A5033940436 @default.
- W3100930159 hasAuthorship W3100930159A5049876579 @default.
- W3100930159 hasAuthorship W3100930159A5078012500 @default.
- W3100930159 hasBestOaLocation W31009301591 @default.
- W3100930159 hasConcept C100691959 @default.
- W3100930159 hasConcept C118552586 @default.
- W3100930159 hasConcept C126322002 @default.
- W3100930159 hasConcept C15490471 @default.
- W3100930159 hasConcept C15744967 @default.
- W3100930159 hasConcept C170493617 @default.