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• W3100951629 endingPage "1079" @default.
• W3100951629 startingPage "1065" @default.
• W3100951629 abstract "Post-Translational Modifications (PTMs) are known to play a critical role in the regulation of the protein functions. Their impact on protein structures, and their link to disorder regions have already been spotted on the past decade. Nonetheless, the high diversity of PTMs types, and the multiple schemes of protein modifications (multiple PTMs, of different types, at different time, etc) make difficult the direct confrontation of PTM annotations and protein structures data.We so analyzed the impact of the residue modifications on the protein structures at local level. Thanks to a dedicated structure database, namely PTM-SD, a large screen of PTMs have been done and analyze at a local protein conformation levels using the structural alphabet Protein Blocks (PBs). We investigated the relation between PTMs and the backbone conformation of modified residues, of their local environment, and at the level of the complete protein structure. The two main PTM types (N-glycosylation and phosphorylation) have been studied in non-redundant datasets, and then, 4 different proteins were focused, covering 3 types of PTMs: N-glycosylation in renin endopeptidase and liver carboxylesterase, phosphorylation in cyclin-dependent kinase 2 (CDK2), and methylation in actin. We observed that PTMs could either stabilize or destabilize the backbone structure, at a local and global scale, and that these effects depend on the PTM types." @default.
• W3100951629 created "2020-11-23" @default.
• W3100951629 creator A5012519708 @default.
• W3100951629 creator A5024376929 @default.
• W3100951629 creator A5042813151 @default.
• W3100951629 creator A5072442246 @default.
• W3100951629 date "2019-06-10" @default.
• W3100951629 modified "2023-10-17" @default.
• W3100951629 title "Investigation of the impact of PTMs on the protein backbone conformation" @default.
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• W3100951629 doi "https://doi.org/10.1007/s00726-019-02747-w" @default.
• W3100951629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31183539" @default.
• W3100951629 hasPublicationYear "2019" @default.
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