Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100952499> ?p ?o ?g. }
- W3100952499 abstract "Abstract While in recent trials the dual pathway inhibition with aspirin plus rivaroxaban has shown to be efficacious in patients with atherosclerotic cardiovascular disease, little is known about the effects of this combination treatment on thrombus formation and vascular remodelling upon vascular damage. The aim of this study was to examine the effects of aspirin and/or rivaroxaban on injury-induced murine arterial thrombus formation in vivo and in vitro, vessel-wall remodelling, and platelet-leukocyte aggregates. Temporary ligation of the carotid artery of C57BL/6 mice, fed a western type diet, led to endothelial denudation and sub-occlusive thrombus formation. At the site of ligation, the vessel wall stiffened and the intima-media thickened. Aspirin treatment antagonized vascular stiffening and rivaroxaban treatment led to a positive trend towards reduced stiffening. Local intima-media thickening was antagonized by both aspirin or rivaroxaban treatment. Platelet-leukocyte aggregates and the number of platelets per leukocyte were reduced in aspirin and/or rivaroxaban treatment groups. Furthermore, rivaroxaban restricted thrombus growth and height in vitro. In sum, this study shows vascular protective effects of aspirin and rivaroxaban, upon vascular injury of the mouse artery." @default.
- W3100952499 created "2020-11-23" @default.
- W3100952499 creator A5002763302 @default.
- W3100952499 creator A5011603361 @default.
- W3100952499 creator A5024752304 @default.
- W3100952499 creator A5025712146 @default.
- W3100952499 creator A5026353068 @default.
- W3100952499 creator A5029495450 @default.
- W3100952499 creator A5037662846 @default.
- W3100952499 creator A5042308845 @default.
- W3100952499 creator A5042698152 @default.
- W3100952499 creator A5043721878 @default.
- W3100952499 creator A5051027118 @default.
- W3100952499 creator A5053346274 @default.
- W3100952499 creator A5066678822 @default.
- W3100952499 creator A5066836069 @default.
- W3100952499 creator A5068782139 @default.
- W3100952499 creator A5073188418 @default.
- W3100952499 date "2020-11-09" @default.
- W3100952499 modified "2023-10-18" @default.
- W3100952499 title "Vascular protective effect of aspirin and rivaroxaban upon endothelial denudation of the mouse carotid artery" @default.
- W3100952499 cites W1579722187 @default.
- W3100952499 cites W1601249330 @default.
- W3100952499 cites W1726466368 @default.
- W3100952499 cites W179729331 @default.
- W3100952499 cites W1800020109 @default.
- W3100952499 cites W1965907001 @default.
- W3100952499 cites W1976679810 @default.
- W3100952499 cites W1984315653 @default.
- W3100952499 cites W1984514918 @default.
- W3100952499 cites W2006307608 @default.
- W3100952499 cites W2016754244 @default.
- W3100952499 cites W2033430377 @default.
- W3100952499 cites W2035963427 @default.
- W3100952499 cites W2036655503 @default.
- W3100952499 cites W2037182281 @default.
- W3100952499 cites W2041777103 @default.
- W3100952499 cites W2078560235 @default.
- W3100952499 cites W2088930618 @default.
- W3100952499 cites W2089871687 @default.
- W3100952499 cites W2090298304 @default.
- W3100952499 cites W2092030100 @default.
- W3100952499 cites W2093070399 @default.
- W3100952499 cites W2100858861 @default.
- W3100952499 cites W2101726084 @default.
- W3100952499 cites W2115796512 @default.
- W3100952499 cites W2118161330 @default.
- W3100952499 cites W2120726327 @default.
- W3100952499 cites W2127897756 @default.
- W3100952499 cites W2130248616 @default.
- W3100952499 cites W2136057525 @default.
- W3100952499 cites W2141015143 @default.
- W3100952499 cites W2153870562 @default.
- W3100952499 cites W2157053766 @default.
- W3100952499 cites W2165122118 @default.
- W3100952499 cites W2178107643 @default.
- W3100952499 cites W2178867594 @default.
- W3100952499 cites W2257416106 @default.
- W3100952499 cites W2293588232 @default.
- W3100952499 cites W2534875391 @default.
- W3100952499 cites W2749380187 @default.
- W3100952499 cites W2761055723 @default.
- W3100952499 cites W2792943263 @default.
- W3100952499 cites W2793685667 @default.
- W3100952499 cites W2795076463 @default.
- W3100952499 cites W2898145250 @default.
- W3100952499 cites W2899449506 @default.
- W3100952499 cites W2940417786 @default.
- W3100952499 cites W2943109321 @default.
- W3100952499 cites W2999215088 @default.
- W3100952499 cites W3003122244 @default.
- W3100952499 cites W3013428853 @default.
- W3100952499 cites W3037187678 @default.
- W3100952499 cites W3050140998 @default.
- W3100952499 cites W3126144668 @default.
- W3100952499 cites W4244893064 @default.
- W3100952499 cites W4322700970 @default.
- W3100952499 doi "https://doi.org/10.1038/s41598-020-76377-8" @default.
- W3100952499 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7653917" @default.
- W3100952499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33168914" @default.
- W3100952499 hasPublicationYear "2020" @default.
- W3100952499 type Work @default.
- W3100952499 sameAs 3100952499 @default.
- W3100952499 citedByCount "3" @default.
- W3100952499 countsByYear W31009524992022 @default.
- W3100952499 countsByYear W31009524992023 @default.
- W3100952499 crossrefType "journal-article" @default.
- W3100952499 hasAuthorship W3100952499A5002763302 @default.
- W3100952499 hasAuthorship W3100952499A5011603361 @default.
- W3100952499 hasAuthorship W3100952499A5024752304 @default.
- W3100952499 hasAuthorship W3100952499A5025712146 @default.
- W3100952499 hasAuthorship W3100952499A5026353068 @default.
- W3100952499 hasAuthorship W3100952499A5029495450 @default.
- W3100952499 hasAuthorship W3100952499A5037662846 @default.
- W3100952499 hasAuthorship W3100952499A5042308845 @default.
- W3100952499 hasAuthorship W3100952499A5042698152 @default.
- W3100952499 hasAuthorship W3100952499A5043721878 @default.
- W3100952499 hasAuthorship W3100952499A5051027118 @default.
- W3100952499 hasAuthorship W3100952499A5053346274 @default.
- W3100952499 hasAuthorship W3100952499A5066678822 @default.