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- W3100961684 abstract "Introduction: Parkinson'sdisease isassociated withirondeposition in the brain. The T2-weighted imaging, T2* mapping, R2 mapping and Quantitative Susceptibility Mapping (QSM) are threecommon methods to evaluating the iron deposition in brain. Among three methods the QSM is more sensitive than others. Few studies have been used QSM for evaluating the iron deposition in the basal ganglia of patients with Parkinson's Disease (PD). Therefore, our aim was to evaluate the amount of iron deposition in the basal ganglia using QSM and determination the diagnostic value of this method; Also we evaluated the relationship between the QSM with age and stage of the disease.Materials and Methods: Thirty patients categorized in three different stages using Hoehn and Yahr tests. The number of 8, 11 and 11 patients were considered for stage 1, stage 2 andstage 3, respectively. Fifteen healthy subjects were considered as control group. MRIsequences were performed using SIEMENS 3T scanner. The SPIN (Signal Processing in NMR)software was used to processing and analyzing the images. The QSM was measured in allbasal ganglia (Red Nucleus, Substantia Nigra, Caudate, Globus Pallidus, Putamen, andThalamus) separately. The SPSS 18 (SPSS Inc., Chicago, IL) used for analyzing the data.Results: There was a significant difference (P-value<0.001) for QSM in the Red Nucleus,Substantia Nigra and Globus Pallidus nuclei between two patient and control group. Therelationship between disease stage with QSM was significant in Red Nucleus (RN), SubstantiaNigra (SN) and Globus Pallidus (GP) nuclei (P-value<0.001). Correlation of QSM with age wasnot significant in any of the nuclei. The accuracy of QSM was 98.0, 86.7 and 88.9 percent forSN, RN and GP. The specificity of QSM was 93.3, 100.0 and 86.7% for SN, RN and GP; Also thesensitivity was 100.0, 80.0 and 90.0 for SN, RN and GP, respectively.Conclusion: Using QSM in RN, SN, and GP nuclei can help diagnosis and staging of patientswith Parkinson's disease. Future studies with emphasis on the disease stage using largersample size can be helpful in evaluation the different sub-parts of these nuclei." @default.
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- W3100961684 date "2018-12-01" @default.
- W3100961684 modified "2023-09-27" @default.
- W3100961684 title "Diagnosis of patients with Parkinson's disease using quantitative susceptibility mapping" @default.
- W3100961684 doi "https://doi.org/10.22038/ijmp.2018.12425" @default.
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