Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100961939> ?p ?o ?g. }
- W3100961939 abstract "Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the symptoms of motor deficits and cognitive decline. There are a number of therapeutics available for the treatment of PD, but most of them suffer from serious side effects such as bradykinesia, dyskinesia and on-off effect. Therefore, despite the availability of these pharmacological agents, PD patients continue to have an inferior quality of life. This has warranted a need to look for alternate strategies and molecular targets. Recent evidence suggests the Transient Receptor Potential (TRP) channels could be a potential target for the management of motor and non-motor symptoms of PD. Though still in the preclinical stages, agents targeting these channels have shown immense potential in the attenuation of behavioral deficits and signaling pathways. In addition, these channels are known to be involved in the regulation of ionic homeostasis, which is disrupted in PD. Moreover, activation or inhibition of many of the TRP channels by calcium and oxidative stress has also raised the possibility of their paramount involvement in affecting the other molecular mechanisms associated with PD pathology. However, due to the paucity of information available and lack of specificity, none of these agents have gone into clinical trials for PD treatment. Considering their interaction with oxidative stress, apoptosis and excitotoxicity, TRP channels could be considered as a potential future target for the treatment of PD." @default.
- W3100961939 created "2020-11-23" @default.
- W3100961939 creator A5039538410 @default.
- W3100961939 creator A5073894886 @default.
- W3100961939 date "2020-11-20" @default.
- W3100961939 modified "2023-10-17" @default.
- W3100961939 title "Transient Receptor Potential Channels as an Emerging Target for the Treatment of Parkinson’s Disease: An Insight Into Role of Pharmacological Interventions" @default.
- W3100961939 cites W1165141362 @default.
- W3100961939 cites W1486153595 @default.
- W3100961939 cites W1511198581 @default.
- W3100961939 cites W1514075515 @default.
- W3100961939 cites W1567917794 @default.
- W3100961939 cites W1571837352 @default.
- W3100961939 cites W1594770614 @default.
- W3100961939 cites W1964358846 @default.
- W3100961939 cites W1964925166 @default.
- W3100961939 cites W1965472844 @default.
- W3100961939 cites W1966809675 @default.
- W3100961939 cites W1967659552 @default.
- W3100961939 cites W1969515779 @default.
- W3100961939 cites W1971180365 @default.
- W3100961939 cites W1974058597 @default.
- W3100961939 cites W1978354565 @default.
- W3100961939 cites W1983781894 @default.
- W3100961939 cites W1988860455 @default.
- W3100961939 cites W1989036219 @default.
- W3100961939 cites W1996462430 @default.
- W3100961939 cites W2000638122 @default.
- W3100961939 cites W2007034094 @default.
- W3100961939 cites W2012225839 @default.
- W3100961939 cites W2021364448 @default.
- W3100961939 cites W2023025537 @default.
- W3100961939 cites W2028626129 @default.
- W3100961939 cites W2029117358 @default.
- W3100961939 cites W2030358163 @default.
- W3100961939 cites W2031511565 @default.
- W3100961939 cites W2033620602 @default.
- W3100961939 cites W2052985285 @default.
- W3100961939 cites W2065128164 @default.
- W3100961939 cites W2066353322 @default.
- W3100961939 cites W2077131862 @default.
- W3100961939 cites W2077515040 @default.
- W3100961939 cites W2078417719 @default.
- W3100961939 cites W2087505476 @default.
- W3100961939 cites W2088231371 @default.
- W3100961939 cites W2094874028 @default.
- W3100961939 cites W2094955398 @default.
- W3100961939 cites W2097283454 @default.
- W3100961939 cites W2099440801 @default.
- W3100961939 cites W2099586601 @default.
- W3100961939 cites W2101007294 @default.
- W3100961939 cites W2101241440 @default.
- W3100961939 cites W2116655439 @default.
- W3100961939 cites W2118490608 @default.
- W3100961939 cites W2131399935 @default.
- W3100961939 cites W2133588840 @default.
- W3100961939 cites W2145376463 @default.
- W3100961939 cites W2146949990 @default.
- W3100961939 cites W2154708260 @default.
- W3100961939 cites W2157941925 @default.
- W3100961939 cites W2158754769 @default.
- W3100961939 cites W2164343761 @default.
- W3100961939 cites W2166997000 @default.
- W3100961939 cites W2168269979 @default.
- W3100961939 cites W2169059319 @default.
- W3100961939 cites W2169319323 @default.
- W3100961939 cites W2169691200 @default.
- W3100961939 cites W2171260594 @default.
- W3100961939 cites W2223781517 @default.
- W3100961939 cites W2319666779 @default.
- W3100961939 cites W2332182291 @default.
- W3100961939 cites W2472577276 @default.
- W3100961939 cites W2515799630 @default.
- W3100961939 cites W2523865002 @default.
- W3100961939 cites W2530148662 @default.
- W3100961939 cites W2563900680 @default.
- W3100961939 cites W2590860127 @default.
- W3100961939 cites W2592049100 @default.
- W3100961939 cites W2594292585 @default.
- W3100961939 cites W2594339539 @default.
- W3100961939 cites W2614168593 @default.
- W3100961939 cites W2615308239 @default.
- W3100961939 cites W2752241260 @default.
- W3100961939 cites W2770812943 @default.
- W3100961939 cites W2791600949 @default.
- W3100961939 cites W2792199596 @default.
- W3100961939 cites W2793367674 @default.
- W3100961939 cites W2802671986 @default.
- W3100961939 cites W2805136369 @default.
- W3100961939 cites W2886115557 @default.
- W3100961939 cites W2887881944 @default.
- W3100961939 cites W2896258198 @default.
- W3100961939 cites W2906771164 @default.
- W3100961939 cites W2910667490 @default.
- W3100961939 cites W2913722971 @default.
- W3100961939 cites W2928437348 @default.
- W3100961939 cites W2936946820 @default.
- W3100961939 cites W2945879979 @default.
- W3100961939 cites W2946289473 @default.
- W3100961939 cites W2971102518 @default.