FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100971424> ?p ?o ?g. }

• W3100971424 endingPage "108357" @default.
• W3100971424 startingPage "108357" @default.
• W3100971424 abstract "Cohesin, a critical mediator of genome organization including sister chromatid cohesion, is a ring-shaped multi-subunit ATPase that topologically embraces DNA. Its loading and function on chromosomes require the Scc2-Scc4 loader. Using biochemical reconstitution, we show here that the ability of the loader to bind DNA plays a critical role in promoting cohesin loading. Two distinct sites within the Mis4Scc2 subunit are found to cooperatively bind DNA. Mis4Scc2 initially forms a tertiary complex with cohesin on DNA and promotes subsequent topological DNA entrapment by cohesin through its DNA binding activity, a process that requires an additional DNA binding surface provided by Psm3Smc3, the ATPase domain of cohesin. Furthermore, we show that mutations in the two DNA binding sites of Mis4 impair the chromosomal loading of cohesin. These observations demonstrate the physiological importance of DNA binding by the loader and provide mechanistic insights into the process of topological cohesin loading." @default.
• W3100971424 created "2020-11-23" @default.
• W3100971424 creator A5019824906 @default.
• W3100971424 creator A5062799181 @default.
• W3100971424 date "2020-11-01" @default.
• W3100971424 modified "2023-09-25" @default.
• W3100971424 title "DNA Binding by the Mis4Scc2 Loader Promotes Topological DNA Entrapment by the Cohesin Ring" @default.
• W3100971424 cites W1728543386 @default.
• W3100971424 cites W1966722475 @default.
• W3100971424 cites W1967920462 @default.
• W3100971424 cites W1972307085 @default.
• W3100971424 cites W1979162302 @default.
• W3100971424 cites W1979298341 @default.
• W3100971424 cites W1996413778 @default.
• W3100971424 cites W2003673194 @default.
• W3100971424 cites W2004304977 @default.
• W3100971424 cites W2013035015 @default.
• W3100971424 cites W2019077723 @default.
• W3100971424 cites W2033470262 @default.
• W3100971424 cites W2042339569 @default.
• W3100971424 cites W2066076039 @default.
• W3100971424 cites W2068625350 @default.
• W3100971424 cites W2084288806 @default.
• W3100971424 cites W2089736577 @default.
• W3100971424 cites W2095639780 @default.
• W3100971424 cites W2127322768 @default.
• W3100971424 cites W2129375037 @default.
• W3100971424 cites W2139189803 @default.
• W3100971424 cites W2149015451 @default.
• W3100971424 cites W2151392117 @default.
• W3100971424 cites W2168621448 @default.
• W3100971424 cites W2198084537 @default.
• W3100971424 cites W2282963281 @default.
• W3100971424 cites W2284990886 @default.
• W3100971424 cites W2296655979 @default.
• W3100971424 cites W2338485081 @default.
• W3100971424 cites W2341542582 @default.
• W3100971424 cites W2530257072 @default.
• W3100971424 cites W2532485011 @default.
• W3100971424 cites W2555146308 @default.
• W3100971424 cites W2571270016 @default.
• W3100971424 cites W2761461280 @default.
• W3100971424 cites W2761651210 @default.
• W3100971424 cites W2783028951 @default.
• W3100971424 cites W2795173023 @default.
• W3100971424 cites W2801189843 @default.
• W3100971424 cites W2809178041 @default.
• W3100971424 cites W2885656579 @default.
• W3100971424 cites W2890122519 @default.
• W3100971424 cites W2894880237 @default.
• W3100971424 cites W2898086195 @default.
• W3100971424 cites W2900190809 @default.
• W3100971424 cites W2922770922 @default.
• W3100971424 cites W2951726997 @default.
• W3100971424 cites W2952348256 @default.
• W3100971424 cites W2977744221 @default.
• W3100971424 cites W2989641336 @default.
• W3100971424 cites W2989713781 @default.
• W3100971424 cites W2991248607 @default.
• W3100971424 cites W3025316148 @default.
• W3100971424 cites W3046933533 @default.
• W3100971424 cites W3086608978 @default.
• W3100971424 doi "https://doi.org/10.1016/j.celrep.2020.108357" @default.
• W3100971424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33176147" @default.
• W3100971424 hasPublicationYear "2020" @default.
• W3100971424 type Work @default.
• W3100971424 sameAs 3100971424 @default.
• W3100971424 citedByCount "10" @default.
• W3100971424 countsByYear W31009714242021 @default.
• W3100971424 countsByYear W31009714242022 @default.
• W3100971424 countsByYear W31009714242023 @default.
• W3100971424 crossrefType "journal-article" @default.
• W3100971424 hasAuthorship W3100971424A5019824906 @default.
• W3100971424 hasAuthorship W3100971424A5062799181 @default.
• W3100971424 hasBestOaLocation W31009714241 @default.
• W3100971424 hasConcept C104317684 @default.
• W3100971424 hasConcept C115821613 @default.
• W3100971424 hasConcept C152369539 @default.
• W3100971424 hasConcept C185592680 @default.
• W3100971424 hasConcept C2778354886 @default.
• W3100971424 hasConcept C30481170 @default.
• W3100971424 hasConcept C54355233 @default.
• W3100971424 hasConcept C552990157 @default.
• W3100971424 hasConcept C83640560 @default.
• W3100971424 hasConcept C86803240 @default.
• W3100971424 hasConcept C95444343 @default.
• W3100971424 hasConceptScore W3100971424C104317684 @default.
• W3100971424 hasConceptScore W3100971424C115821613 @default.
• W3100971424 hasConceptScore W3100971424C152369539 @default.
• W3100971424 hasConceptScore W3100971424C185592680 @default.
• W3100971424 hasConceptScore W3100971424C2778354886 @default.
• W3100971424 hasConceptScore W3100971424C30481170 @default.
• W3100971424 hasConceptScore W3100971424C54355233 @default.
• W3100971424 hasConceptScore W3100971424C552990157 @default.
• W3100971424 hasConceptScore W3100971424C83640560 @default.
• W3100971424 hasConceptScore W3100971424C86803240 @default.
• W3100971424 hasConceptScore W3100971424C95444343 @default.
• W3100971424 hasFunder F4320309785 @default.

• next