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• W3100978500 abstract "Abstract Single nucleus RNA-Seq (snRNA-Seq) methods are used as an alternative to single cell RNA-Seq methods, as they allow transcriptomic profiling of frozen tissue. However, it is unclear whether snRNA-Seq is able to detect cellular state in human tissue. Indeed, snRNA-Seq analyses of human brain samples have failed to detect a consistent microglial activation signature in Alzheimer’s Disease. A comparison of microglia from single cells and single nuclei of four human subjects reveals that ~1% of genes is depleted in nuclei compared to whole cells. This small population contains 18% of genes previously implicated in microglial activation, including APOE, CST3, FTL, SPP1 , and CD74 . We confirm our findings across multiple previous single nucleus and single cell studies. Given the low sensitivity of snRNA-Seq to this population of activation genes, we conclude that snRNA-Seq is not suited to detecting cellular activation in microglia in human disease." @default.
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• W3100978500 date "2020-04-13" @default.
• W3100978500 modified "2023-10-06" @default.
• W3100978500 title "Single nucleus sequencing fails to detect microglial activation in human tissue" @default.
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• W3100978500 doi "https://doi.org/10.1101/2020.04.13.035386" @default.
• W3100978500 hasPublicationYear "2020" @default.
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