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- W3100988072 abstract "The development of human cell-based systems to replace the use of rodents or the two-dimensional culture of cells for studying nephrotoxicity is urgently needed. Human urine-derived stem cells were differentiated into renal tubular epithelial cells in three-dimensional (3-D) culture after being induced by a kidney extracellular matrix. Levels of CYP2E1 and KIM-1 in 3-D organoids were significantly increased in response to acetone and cisplatin. This 3-D culture system provides an alternative tool for nephrotoxicity screening and research." @default.
- W3100988072 created "2020-11-23" @default.
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- W3100988072 date "2020-11-13" @default.
- W3100988072 modified "2023-10-14" @default.
- W3100988072 title "3-D Human Renal Tubular Organoids Generated from Urine-Derived Stem Cells for Nephrotoxicity Screening" @default.
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- W3100988072 doi "https://doi.org/10.1021/acsbiomaterials.0c01468" @default.
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