FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100989718> ?p ?o ?g. }

• W3100989718 abstract "Scientists routinely compare gene expression levels in cases versus controls in part to determine genes associated with a disease. Similarly, detecting case-control differences in co-expression among genes can be critical to understanding complex human diseases; however, statistical methods have been limited by the high-dimensional nature of this problem. In this paper, we construct a sparse-Leading-Eigenvalue-Driven (sLED) test for comparing two high-dimensional covariance matrices. By focusing on the spectrum of the differential matrix, sLED provides a novel perspective that accommodates what we assume to be common, namely sparse and weak signals in gene expression data, and it is closely related with sparse principal component analysis. We prove that sLED achieves full power asymptotically under mild assumptions, and simulation studies verify that it outperforms other existing procedures under many biologically plausible scenarios. Applying sLED to the largest gene-expression dataset obtained from post-mortem brain tissue from Schizophrenia patients and controls, we provide a novel list of genes implicated in Schizophrenia and reveal intriguing patterns in gene co-expression change for Schizophrenia subjects. We also illustrate that sLED can be generalized to compare other gene-gene “relationship” matrices that are of practical interest, such as the weighted adjacency matrices." @default.
• W3100989718 created "2020-11-23" @default.
• W3100989718 creator A5021301519 @default.
• W3100989718 creator A5056538801 @default.
• W3100989718 creator A5077476842 @default.
• W3100989718 creator A5085887576 @default.
• W3100989718 date "2017-09-01" @default.
• W3100989718 modified "2023-09-30" @default.
• W3100989718 title "Testing high-dimensional covariance matrices, with application to detecting schizophrenia risk genes" @default.
• W3100989718 cites W1419241926 @default.
• W3100989718 cites W1968224663 @default.
• W3100989718 cites W1975900269 @default.
• W3100989718 cites W1979365023 @default.
• W3100989718 cites W1992362262 @default.
• W3100989718 cites W2006452405 @default.
• W3100989718 cites W2018271831 @default.
• W3100989718 cites W2041062137 @default.
• W3100989718 cites W2044809283 @default.
• W3100989718 cites W2060705109 @default.
• W3100989718 cites W2070050178 @default.
• W3100989718 cites W2083252561 @default.
• W3100989718 cites W2091825839 @default.
• W3100989718 cites W2097714737 @default.
• W3100989718 cites W2098290597 @default.
• W3100989718 cites W2098597355 @default.
• W3100989718 cites W2101357408 @default.
• W3100989718 cites W2105527159 @default.
• W3100989718 cites W2110355775 @default.
• W3100989718 cites W2113600901 @default.
• W3100989718 cites W2132297623 @default.
• W3100989718 cites W2206277886 @default.
• W3100989718 cites W2339469603 @default.
• W3100989718 cites W2526546796 @default.
• W3100989718 cites W2615253071 @default.
• W3100989718 cites W3100989718 @default.
• W3100989718 cites W3103619894 @default.
• W3100989718 cites W4211145950 @default.
• W3100989718 doi "https://doi.org/10.1214/17-aoas1062" @default.
• W3100989718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5655846" @default.
• W3100989718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29081874" @default.
• W3100989718 hasPublicationYear "2017" @default.
• W3100989718 type Work @default.
• W3100989718 sameAs 3100989718 @default.
• W3100989718 citedByCount "20" @default.
• W3100989718 countsByYear W31009897182017 @default.
• W3100989718 countsByYear W31009897182018 @default.
• W3100989718 countsByYear W31009897182019 @default.
• W3100989718 countsByYear W31009897182020 @default.
• W3100989718 countsByYear W31009897182021 @default.
• W3100989718 countsByYear W31009897182022 @default.
• W3100989718 countsByYear W31009897182023 @default.
• W3100989718 crossrefType "journal-article" @default.
• W3100989718 hasAuthorship W3100989718A5021301519 @default.
• W3100989718 hasAuthorship W3100989718A5056538801 @default.
• W3100989718 hasAuthorship W3100989718A5077476842 @default.
• W3100989718 hasAuthorship W3100989718A5085887576 @default.
• W3100989718 hasBestOaLocation W31009897181 @default.
• W3100989718 hasConcept C104317684 @default.
• W3100989718 hasConcept C105795698 @default.
• W3100989718 hasConcept C11413529 @default.
• W3100989718 hasConcept C132525143 @default.
• W3100989718 hasConcept C153180895 @default.
• W3100989718 hasConcept C154945302 @default.
• W3100989718 hasConcept C178650346 @default.
• W3100989718 hasConcept C180356752 @default.
• W3100989718 hasConcept C185142706 @default.
• W3100989718 hasConcept C199360897 @default.
• W3100989718 hasConcept C27438332 @default.
• W3100989718 hasConcept C2776412080 @default.
• W3100989718 hasConcept C33923547 @default.
• W3100989718 hasConcept C41008148 @default.
• W3100989718 hasConcept C54355233 @default.
• W3100989718 hasConcept C70721500 @default.
• W3100989718 hasConcept C80444323 @default.
• W3100989718 hasConcept C86803240 @default.
• W3100989718 hasConcept C90559484 @default.
• W3100989718 hasConceptScore W3100989718C104317684 @default.
• W3100989718 hasConceptScore W3100989718C105795698 @default.
• W3100989718 hasConceptScore W3100989718C11413529 @default.
• W3100989718 hasConceptScore W3100989718C132525143 @default.
• W3100989718 hasConceptScore W3100989718C153180895 @default.
• W3100989718 hasConceptScore W3100989718C154945302 @default.
• W3100989718 hasConceptScore W3100989718C178650346 @default.
• W3100989718 hasConceptScore W3100989718C180356752 @default.
• W3100989718 hasConceptScore W3100989718C185142706 @default.
• W3100989718 hasConceptScore W3100989718C199360897 @default.
• W3100989718 hasConceptScore W3100989718C27438332 @default.
• W3100989718 hasConceptScore W3100989718C2776412080 @default.
• W3100989718 hasConceptScore W3100989718C33923547 @default.
• W3100989718 hasConceptScore W3100989718C41008148 @default.
• W3100989718 hasConceptScore W3100989718C54355233 @default.
• W3100989718 hasConceptScore W3100989718C70721500 @default.
• W3100989718 hasConceptScore W3100989718C80444323 @default.
• W3100989718 hasConceptScore W3100989718C86803240 @default.
• W3100989718 hasConceptScore W3100989718C90559484 @default.
• W3100989718 hasIssue "3" @default.
• W3100989718 hasLocation W31009897181 @default.
• W3100989718 hasLocation W31009897182 @default.
• W3100989718 hasLocation W31009897183 @default.
• W3100989718 hasLocation W31009897184 @default.

• next