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• W3100990055 abstract "Abstract Background The Drosophila hindgut is commonly used model for studying various aspects of organogenesis like primordium establishment, further specification, patterning, and morphogenesis. During embryonic development of Drosophila , many transcriptional activators are involved in the formation of the hindgut. The transcription factor Orthopedia (Otp), a member of the 57B homeobox gene cluster, is expressed in the hindgut and nervous system of developing Drosophila embryos, but due to the lack of mutants no functional analysis has been conducted yet. Results We show that two different otp transcripts, a hindgut-specific and a nervous system-specific form, are present in the Drosophila embryo. Using an Otp antibody, a detailed expression analysis during hindgut development was carried out. Otp was not only expressed in the embryonic hindgut, but also in the larval and adult hindgut. To analyse the function of otp , we generated the mutant otp allele otp GT by ends-out gene targeting. In addition, we isolated two EMS-induced otp alleles in a genetic screen for mutants of the 57B region. All three otp alleles showed embryonic lethality with a severe hindgut phenotype. Anal pads were reduced and the large intestine was completely missing. This phenotype is due to apoptosis in the hindgut primordium and the developing hindgut. Conclusion Our data suggest that Otp is another important factor for hindgut development of Drosophila . As a downstream factor of byn Otp is most likely present only in differentiated hindgut cells during all stages of development rather than in stem cells." @default.
• W3100990055 created "2020-11-23" @default.
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• W3100990055 date "2020-11-19" @default.
• W3100990055 modified "2023-09-26" @default.
• W3100990055 title "The homeodomain transcription factor Orthopedia is involved in development of the Drosophila hindgut" @default.
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• W3100990055 doi "https://doi.org/10.1186/s41065-020-00160-y" @default.
• W3100990055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7678101" @default.
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