FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100990162> ?p ?o ?g. }

• W3100990162 endingPage "jnumed.120.253575" @default.
• W3100990162 startingPage "jnumed.120.253575" @default.
• W3100990162 abstract "Despite efforts in prevention, cervical cancer still presents with a high worldwide incidence and remains a great problem in public health, especially in low-income countries. Screening programs, such as colposcopy with Papanicolaou testing, have greatly improved mortality rates. However, the agents currently used to delineate those lesions (topical application of acetic acid or Lugol iodine) lack specificity and sometimes can lead to unnecessary biopsies or even cervical excisions. A tool to enable in vivo histology to quickly and quantitatively distinguish between tumor, dysplastic tissue, and healthy tissue would be of great clinical interest. <b>Methods:</b> Here, we describe the use of PARPi-FL, a fluorescent inhibitor of poly[adenosine diphosphate-ribose]polymerase 1 (PARP1), which is a nuclear enzyme that is overexpressed in cancer when compared with the normal surrounding tissues. We exploit its use as an optical imaging agent to specifically target PARP1 expression, which was demonstrated to be higher in cervical cancer than the normal surrounding tissue. <b>Results:</b> After topical application of PARPi-FL on freshly excised cone biopsy samples, the nuclei of tumor cells emitted a specific fluorescent signal that could be visualized using a handheld fluorescence confocal microscope. <b>Conclusion:</b> This approach has the potential to improve in vivo identification of tumor cells during colposcopy examination, allowing a rapid, noninvasive, and accurate histopathologic assessment." @default.
• W3100990162 created "2020-11-23" @default.
• W3100990162 creator A5005173946 @default.
• W3100990162 creator A5005883827 @default.
• W3100990162 creator A5018908749 @default.
• W3100990162 creator A5019663026 @default.
• W3100990162 creator A5026131694 @default.
• W3100990162 creator A5027645686 @default.
• W3100990162 creator A5041753819 @default.
• W3100990162 creator A5070777856 @default.
• W3100990162 creator A5072384821 @default.
• W3100990162 creator A5078966058 @default.
• W3100990162 creator A5086109488 @default.
• W3100990162 creator A5088776966 @default.
• W3100990162 date "2020-11-13" @default.
• W3100990162 modified "2023-10-17" @default.
• W3100990162 title "Poly(ADP-ribose)polymerase1: A potential molecular marker to identify cancer during colposcopy procedures." @default.
• W3100990162 cites W1214896322 @default.
• W3100990162 cites W2049136941 @default.
• W3100990162 cites W2087914076 @default.
• W3100990162 cites W2114080746 @default.
• W3100990162 cites W2148612822 @default.
• W3100990162 cites W2150594642 @default.
• W3100990162 cites W2164484098 @default.
• W3100990162 cites W2269359258 @default.
• W3100990162 cites W2282523322 @default.
• W3100990162 cites W2431934307 @default.
• W3100990162 cites W2538260335 @default.
• W3100990162 cites W2560218177 @default.
• W3100990162 cites W2590243799 @default.
• W3100990162 cites W2611270172 @default.
• W3100990162 cites W2622602879 @default.
• W3100990162 cites W2737389832 @default.
• W3100990162 cites W2749512963 @default.
• W3100990162 cites W2783441257 @default.
• W3100990162 cites W2789641171 @default.
• W3100990162 cites W2806421431 @default.
• W3100990162 cites W2886477543 @default.
• W3100990162 cites W2888263423 @default.
• W3100990162 cites W2895926103 @default.
• W3100990162 cites W2946745534 @default.
• W3100990162 cites W2951058429 @default.
• W3100990162 cites W2955782453 @default.
• W3100990162 cites W2965145700 @default.
• W3100990162 cites W2993849036 @default.
• W3100990162 cites W3001747403 @default.
• W3100990162 cites W3003249044 @default.
• W3100990162 cites W3005409872 @default.
• W3100990162 cites W3006291100 @default.
• W3100990162 cites W3012328527 @default.
• W3100990162 cites W3014754175 @default.
• W3100990162 cites W3040649190 @default.
• W3100990162 doi "https://doi.org/10.2967/jnumed.120.253575" @default.
• W3100990162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33188153" @default.
• W3100990162 hasPublicationYear "2020" @default.
• W3100990162 type Work @default.
• W3100990162 sameAs 3100990162 @default.
• W3100990162 citedByCount "3" @default.
• W3100990162 countsByYear W31009901622021 @default.
• W3100990162 countsByYear W31009901622022 @default.
• W3100990162 countsByYear W31009901622023 @default.
• W3100990162 crossrefType "journal-article" @default.
• W3100990162 hasAuthorship W3100990162A5005173946 @default.
• W3100990162 hasAuthorship W3100990162A5005883827 @default.
• W3100990162 hasAuthorship W3100990162A5018908749 @default.
• W3100990162 hasAuthorship W3100990162A5019663026 @default.
• W3100990162 hasAuthorship W3100990162A5026131694 @default.
• W3100990162 hasAuthorship W3100990162A5027645686 @default.
• W3100990162 hasAuthorship W3100990162A5041753819 @default.
• W3100990162 hasAuthorship W3100990162A5070777856 @default.
• W3100990162 hasAuthorship W3100990162A5072384821 @default.
• W3100990162 hasAuthorship W3100990162A5078966058 @default.
• W3100990162 hasAuthorship W3100990162A5086109488 @default.
• W3100990162 hasAuthorship W3100990162A5088776966 @default.
• W3100990162 hasBestOaLocation W31009901621 @default.
• W3100990162 hasConcept C121608353 @default.
• W3100990162 hasConcept C126322002 @default.
• W3100990162 hasConcept C142724271 @default.
• W3100990162 hasConcept C150903083 @default.
• W3100990162 hasConcept C181199279 @default.
• W3100990162 hasConcept C182979987 @default.
• W3100990162 hasConcept C207001950 @default.
• W3100990162 hasConcept C2775934546 @default.
• W3100990162 hasConcept C2776117191 @default.
• W3100990162 hasConcept C2778220009 @default.
• W3100990162 hasConcept C2778480876 @default.
• W3100990162 hasConcept C502942594 @default.
• W3100990162 hasConcept C55493867 @default.
• W3100990162 hasConcept C71924100 @default.
• W3100990162 hasConcept C82381507 @default.
• W3100990162 hasConcept C86803240 @default.
• W3100990162 hasConceptScore W3100990162C121608353 @default.
• W3100990162 hasConceptScore W3100990162C126322002 @default.
• W3100990162 hasConceptScore W3100990162C142724271 @default.
• W3100990162 hasConceptScore W3100990162C150903083 @default.
• W3100990162 hasConceptScore W3100990162C181199279 @default.
• W3100990162 hasConceptScore W3100990162C182979987 @default.
• W3100990162 hasConceptScore W3100990162C207001950 @default.

• next