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• W3100994328 abstract "Significance The endoplasmic reticulum (ER) serves as the major intracellular calcium store. The release of calcium from this store regulates a variety of cellular functions, hence playing a key role in regulating apoptosis. The transmembrane BAX inhibitor-1 motif-containing 6 (TMBIM6) is an evolutionarily conserved multifunctional ER membrane protein that mediates calcium homeostasis to protect against apoptosis and ER stress. We study a bacterial homolog of TMBIM6 and report several previously unidentified conformational substates involved in the calcium transport process. Our findings stimulate a model of calcium-release channel showing that membrane protein functioning requires the interconversion between distinct conformations in preexisting conformational equilibria." @default.
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• W3100994328 date "2020-11-18" @default.
• W3100994328 modified "2023-10-09" @default.
• W3100994328 title "Structure and regulation of the BsYetJ calcium channel in lipid nanodiscs" @default.
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• W3100994328 doi "https://doi.org/10.1073/pnas.2014094117" @default.
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