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• W3101212880 startingPage "103" @default.
• W3101212880 abstract "Liver cancer is a global problem and hepatocellular carcinoma (HCC) accounts for about 85% of this cancer. In the USA, etiologies and risk factors for HCC include chronic hepatitis C virus (HCV) infection, diabetes, non-alcoholic steatohepatitis (NASH), obesity, excessive alcohol drinking, exposure to tobacco smoke, and genetic factors. Chronic HCV infection appears to be associated with about 30% of HCC. Chronic HCV infection induces multistep changes in liver, involving metabolic disorders, steatosis, cirrhosis and HCC. Liver carcinogenesis requires initiation of neoplastic clones, and progression to clinically diagnose malignancy. Tumor progression associates with profound exhaustion of tumor-antigen-specific CD8+T cells, and accumulation of PD-1hi CD8+T cells and Tregs. In this chapter, we provide a brief description of HCV and environmental/genetic factors, immune regulation, and highlight mechanisms of HCV associated HCC. We also underscore HCV treatment and recent paradigm of HCC progression, highlighted the current treatment and potential future therapeutic opportunities." @default.
• W3101212880 created "2020-11-23" @default.
• W3101212880 creator A5027940255 @default.
• W3101212880 creator A5070690016 @default.
• W3101212880 creator A5070904348 @default.
• W3101212880 date "2021-01-01" @default.
• W3101212880 modified "2023-09-30" @default.
• W3101212880 title "Hepatitis C virus associated hepatocellular carcinoma" @default.
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