FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3101276012> ?p ?o ?g. }

• W3101276012 endingPage "1506" @default.
• W3101276012 startingPage "1506" @default.
• W3101276012 abstract "Previous studies have reported that Xiaoyaosan (XYS), Tiaogan-Liqi therapy, has a protective function in depressive disorder, and can regulate body weight and corticosterone (CORT) level. However, little is known about the effect of XYS in treating atherosclerosis. This study aimed to explore the influence XYS on macrophage foam cell formation and related mechanism.Rat peritoneal macrophages (PMs) were separated and stimulated with CORT and oxidized low density lipoprotein (ox-LDL). The serum was obtained from rats treated with different doses of XYS and was added into the medium for macrophages. Then, the cell activity and lipid content of PMs were measured through Cell Counting Kit-8 (CCK-8) assay and oil red staining, respectively. The expressions of glucocorticoid receptor (GR), ATP binding cassette subfamily A member 1 (ABCA1), and heat shock protein 90 (HSP90) were detected. In addition, overexpression of GR and ABCA1 was performed and the effect on XYS treatment was subsequently assessed.The CCK-8 assay showed the serum increased cell activity of CORT-induced stress PMs in a XYS dose-dependent manner. Oil red staining and enzyme-linked immunosorbent assay (ELISA) showed that the serum decreased lipids of PMs. In the XYS treated groups, HSP90 protein was decreased and protein levels of ABCA1 and GR were increased in cytoplasm, while GR protein in nucleus was decreased. Co-immunoprecipitation (Co-IP) assay indicated GR might interact with HSP90 and be involved with the function of XYS. Furthermore, overexpression of GR attenuated the protective function of XYS on CORT-induced stress in PMs, while overexpression of ABCA1 enhanced that.This study denoted that XYS could protect PMs from CORT-induced stress by regulating the interaction of GR and ABCA1, which might contribute to the treatment of atherosclerosis." @default.
• W3101276012 created "2020-11-23" @default.
• W3101276012 creator A5021269788 @default.
• W3101276012 creator A5025976511 @default.
• W3101276012 creator A5032040055 @default.
• W3101276012 creator A5037797498 @default.
• W3101276012 creator A5039033480 @default.
• W3101276012 creator A5047656558 @default.
• W3101276012 creator A5055601698 @default.
• W3101276012 creator A5080449280 @default.
• W3101276012 creator A5087808961 @default.
• W3101276012 date "2020-11-01" @default.
• W3101276012 modified "2023-09-23" @default.
• W3101276012 title "Xiaoyaosan (Tiaogan-Liqi therapy) protects peritoneal macrophages from corticosterone-induced stress by regulating the interaction between glucocorticoid receptor and ABCA1" @default.
• W3101276012 cites W1983803824 @default.
• W3101276012 cites W2020219815 @default.
• W3101276012 cites W2021938836 @default.
• W3101276012 cites W2031920761 @default.
• W3101276012 cites W2039641387 @default.
• W3101276012 cites W2045288044 @default.
• W3101276012 cites W2067091285 @default.
• W3101276012 cites W2122918348 @default.
• W3101276012 cites W2166543067 @default.
• W3101276012 cites W2171572809 @default.
• W3101276012 cites W2188414910 @default.
• W3101276012 cites W2302238410 @default.
• W3101276012 cites W2415197886 @default.
• W3101276012 cites W2583164539 @default.
• W3101276012 cites W2596585859 @default.
• W3101276012 cites W2605395214 @default.
• W3101276012 cites W2748451439 @default.
• W3101276012 cites W2757897343 @default.
• W3101276012 cites W2770793643 @default.
• W3101276012 cites W2771413736 @default.
• W3101276012 cites W2783025516 @default.
• W3101276012 cites W2796308789 @default.
• W3101276012 cites W2799855321 @default.
• W3101276012 cites W2810620131 @default.
• W3101276012 cites W2905314657 @default.
• W3101276012 cites W2910257112 @default.
• W3101276012 cites W2984179646 @default.
• W3101276012 cites W3011056162 @default.
• W3101276012 cites W764336259 @default.
• W3101276012 cites W803479915 @default.
• W3101276012 cites W2969405542 @default.
• W3101276012 doi "https://doi.org/10.21037/atm-20-6505" @default.
• W3101276012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7729347" @default.
• W3101276012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33313251" @default.
• W3101276012 hasPublicationYear "2020" @default.
• W3101276012 type Work @default.
• W3101276012 sameAs 3101276012 @default.
• W3101276012 citedByCount "1" @default.
• W3101276012 countsByYear W31012760122022 @default.
• W3101276012 crossrefType "journal-article" @default.
• W3101276012 hasAuthorship W3101276012A5021269788 @default.
• W3101276012 hasAuthorship W3101276012A5025976511 @default.
• W3101276012 hasAuthorship W3101276012A5032040055 @default.
• W3101276012 hasAuthorship W3101276012A5037797498 @default.
• W3101276012 hasAuthorship W3101276012A5039033480 @default.
• W3101276012 hasAuthorship W3101276012A5047656558 @default.
• W3101276012 hasAuthorship W3101276012A5055601698 @default.
• W3101276012 hasAuthorship W3101276012A5080449280 @default.
• W3101276012 hasAuthorship W3101276012A5087808961 @default.
• W3101276012 hasBestOaLocation W31012760121 @default.
• W3101276012 hasConcept C104317684 @default.
• W3101276012 hasConcept C126322002 @default.
• W3101276012 hasConcept C134018914 @default.
• W3101276012 hasConcept C149011108 @default.
• W3101276012 hasConcept C185592680 @default.
• W3101276012 hasConcept C205260736 @default.
• W3101276012 hasConcept C2776330080 @default.
• W3101276012 hasConcept C2777704780 @default.
• W3101276012 hasConcept C2780352252 @default.
• W3101276012 hasConcept C2780841215 @default.
• W3101276012 hasConcept C55493867 @default.
• W3101276012 hasConcept C59493245 @default.
• W3101276012 hasConcept C71315377 @default.
• W3101276012 hasConcept C71924100 @default.
• W3101276012 hasConcept C86803240 @default.
• W3101276012 hasConcept C98274493 @default.
• W3101276012 hasConceptScore W3101276012C104317684 @default.
• W3101276012 hasConceptScore W3101276012C126322002 @default.
• W3101276012 hasConceptScore W3101276012C134018914 @default.
• W3101276012 hasConceptScore W3101276012C149011108 @default.
• W3101276012 hasConceptScore W3101276012C185592680 @default.
• W3101276012 hasConceptScore W3101276012C205260736 @default.
• W3101276012 hasConceptScore W3101276012C2776330080 @default.
• W3101276012 hasConceptScore W3101276012C2777704780 @default.
• W3101276012 hasConceptScore W3101276012C2780352252 @default.
• W3101276012 hasConceptScore W3101276012C2780841215 @default.
• W3101276012 hasConceptScore W3101276012C55493867 @default.
• W3101276012 hasConceptScore W3101276012C59493245 @default.
• W3101276012 hasConceptScore W3101276012C71315377 @default.
• W3101276012 hasConceptScore W3101276012C71924100 @default.
• W3101276012 hasConceptScore W3101276012C86803240 @default.
• W3101276012 hasConceptScore W3101276012C98274493 @default.
• W3101276012 hasIssue "22" @default.
• W3101276012 hasLocation W31012760121 @default.

• next