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- W3101276404 endingPage "100930" @default.
- W3101276404 startingPage "100930" @default.
- W3101276404 abstract "The immune landscape of a tumor is highly connected to patient prognosis and response to treatment, but little is known about how natural killer (NK) cells predict overall survival (OS) among patients with solid tumors. We present the first meta-analysis on NK cell infiltration into solid tumors as a prognostic indicator for OS, considering cancer types independently, and together. Samples were collected from 1973 to 2016 with results published between 1989 and 2020. From 53 studies, we found that NK cell infiltration corresponds with decreased risk of death (HR=0.34, 95% CI: 0.26–0.46; p<0.0001). Among studies that investigated the prognostic potential of NK cells in specific regions of the tumor, intraepithelial infiltration was better predictive of OS than NK infiltration in the tumor-adjacent stroma. Generally, NK cell infiltration is lower in advanced-stage and lower-grade tumors; nevertheless, it remains prognostically beneficial. This meta-analysis highlights an important prognostic role of NK cells in solid tumors, but exposes that few studies have considered the contributions of NK cells. Toward NK cell-based immunotherapies, it will be important to understand the conditions under which NK cells can be effective agents of tumor control." @default.
- W3101276404 created "2020-11-23" @default.
- W3101276404 creator A5038754805 @default.
- W3101276404 creator A5050103952 @default.
- W3101276404 creator A5055456849 @default.
- W3101276404 creator A5057045279 @default.
- W3101276404 creator A5067080778 @default.
- W3101276404 creator A5081161048 @default.
- W3101276404 creator A5088189511 @default.
- W3101276404 date "2021-01-01" @default.
- W3101276404 modified "2023-10-13" @default.
- W3101276404 title "NK cell infiltration is associated with improved overall survival in solid cancers: A systematic review and meta-analysis" @default.
- W3101276404 cites W1494194796 @default.
- W3101276404 cites W1550322418 @default.
- W3101276404 cites W1665384871 @default.
- W3101276404 cites W166987468 @default.
- W3101276404 cites W1849978153 @default.
- W3101276404 cites W1910203605 @default.
- W3101276404 cites W1963939177 @default.
- W3101276404 cites W1965119596 @default.
- W3101276404 cites W1973686381 @default.
- W3101276404 cites W1977763841 @default.
- W3101276404 cites W1983012273 @default.
- W3101276404 cites W1987755269 @default.
- W3101276404 cites W1987977871 @default.
- W3101276404 cites W1989712520 @default.
- W3101276404 cites W1994932725 @default.
- W3101276404 cites W2003635644 @default.
- W3101276404 cites W2008658155 @default.
- W3101276404 cites W2012241904 @default.
- W3101276404 cites W2013183060 @default.
- W3101276404 cites W2013224779 @default.
- W3101276404 cites W2019994548 @default.
- W3101276404 cites W2027542837 @default.
- W3101276404 cites W2027726380 @default.
- W3101276404 cites W2033296826 @default.
- W3101276404 cites W2035013975 @default.
- W3101276404 cites W2040891129 @default.
- W3101276404 cites W2043723361 @default.
- W3101276404 cites W2044886076 @default.
- W3101276404 cites W2046731919 @default.
- W3101276404 cites W2046764077 @default.
- W3101276404 cites W2049491375 @default.
- W3101276404 cites W2050650374 @default.
- W3101276404 cites W2054272344 @default.
- W3101276404 cites W2057781614 @default.
- W3101276404 cites W2059269711 @default.
- W3101276404 cites W2061262594 @default.
- W3101276404 cites W2061385235 @default.
- W3101276404 cites W2065094930 @default.
- W3101276404 cites W2066368614 @default.
- W3101276404 cites W2071742694 @default.
- W3101276404 cites W2076845157 @default.
- W3101276404 cites W2080826082 @default.
- W3101276404 cites W2082158071 @default.
- W3101276404 cites W2087590625 @default.
- W3101276404 cites W2096069362 @default.
- W3101276404 cites W2104584195 @default.
- W3101276404 cites W2105494088 @default.
- W3101276404 cites W2110232771 @default.
- W3101276404 cites W2111960266 @default.
- W3101276404 cites W2113492727 @default.
- W3101276404 cites W2120687087 @default.
- W3101276404 cites W2124505866 @default.
- W3101276404 cites W2130401210 @default.
- W3101276404 cites W2131365811 @default.
- W3101276404 cites W2135202266 @default.
- W3101276404 cites W2141884708 @default.
- W3101276404 cites W2144734552 @default.
- W3101276404 cites W2144776283 @default.
- W3101276404 cites W2146017741 @default.
- W3101276404 cites W2154270347 @default.
- W3101276404 cites W2156375860 @default.
- W3101276404 cites W2162377851 @default.
- W3101276404 cites W2163196794 @default.
- W3101276404 cites W2165360012 @default.
- W3101276404 cites W2168249395 @default.
- W3101276404 cites W2170394385 @default.
- W3101276404 cites W2196153781 @default.
- W3101276404 cites W2287383446 @default.
- W3101276404 cites W2317416276 @default.
- W3101276404 cites W2329107713 @default.
- W3101276404 cites W2343682798 @default.
- W3101276404 cites W2346326630 @default.
- W3101276404 cites W2409788979 @default.
- W3101276404 cites W2469469957 @default.
- W3101276404 cites W2482252912 @default.
- W3101276404 cites W2518717449 @default.
- W3101276404 cites W2526011086 @default.
- W3101276404 cites W2563951141 @default.
- W3101276404 cites W2587288954 @default.
- W3101276404 cites W2606724481 @default.
- W3101276404 cites W2618327597 @default.
- W3101276404 cites W2625828870 @default.
- W3101276404 cites W2725375820 @default.
- W3101276404 cites W2739276243 @default.
- W3101276404 cites W2740001104 @default.
- W3101276404 cites W2753778520 @default.