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• W3101291459 abstract "A severe immune response in patients with coronavirus disease 2019 (COVID‑19) can cause a potentially lethal unconstrained inflammatory cytokine storm, known as cytokine release syndrome (CRS). The present study provides an overview of the biology underlying CRS and how targeted inhibition of interleukin (IL)‑6 signaling may improve outcomes and the survival of patients suffering from COVID‑19. Preliminary clinical results have indicated that antagonism of the IL‑6 receptor (IL‑6R), including with the FDA‑approved humanized monoclonal antibody tocilizumab, can improve the outcomes of patients with severe or critical COVID‑19 while maintaining a good safety profile. The available clinical data support the expansion of clinical trials using IL‑6R targeting inhibitors for severe and critical COVID‑19 treatment." @default.
• W3101291459 created "2020-11-23" @default.
• W3101291459 creator A5015099972 @default.
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• W3101291459 date "2020-11-09" @default.
• W3101291459 modified "2023-10-16" @default.
• W3101291459 title "Interleukin‑6 signaling blockade treatment for cytokine release syndrome in COVID‑19 (Review)" @default.
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• W3101291459 doi "https://doi.org/10.3892/etm.2020.9456" @default.
• W3101291459 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7690237" @default.
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