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- W3101299715 endingPage "1575" @default.
- W3101299715 startingPage "1575" @default.
- W3101299715 abstract "The potential therapeutic use of some Cannabis sativa plant compounds has been attracting great interest, especially for managing neuropsychiatric disorders due to the relative lack of efficacy of the current treatments. Numerous studies have been carried out using the main phytocannabinoids, tetrahydrocannabinol (THC) and cannabidiol (CBD). CBD displays an interesting pharmacological profile without the potential for becoming a drug of abuse, unlike THC. In this review, we focused on the anxiolytic, antidepressant, and antipsychotic effects of CBD found in animal and human studies. In rodents, results suggest that the effects of CBD depend on the dose, the strain, the administration time course (acute vs. chronic), and the route of administration. In addition, certain key targets have been related with these CBD pharmacological actions, including cannabinoid receptors (CB1r and CB2r), 5-HT1A receptor and neurogenesis factors. Preliminary clinical trials also support the efficacy of CBD as an anxiolytic, antipsychotic, and antidepressant, and more importantly, a positive risk-benefit profile. These promising results support the development of large-scale studies to further evaluate CBD as a potential new drug for the treatment of these psychiatric disorders." @default.
- W3101299715 created "2020-11-23" @default.
- W3101299715 creator A5004097414 @default.
- W3101299715 creator A5020780126 @default.
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- W3101299715 creator A5034660687 @default.
- W3101299715 creator A5054844397 @default.
- W3101299715 creator A5066939418 @default.
- W3101299715 date "2020-11-19" @default.
- W3101299715 modified "2023-10-18" @default.
- W3101299715 title "Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders" @default.
- W3101299715 cites W1166458116 @default.
- W3101299715 cites W1246635139 @default.
- W3101299715 cites W1490681631 @default.
- W3101299715 cites W1497893548 @default.
- W3101299715 cites W1553366132 @default.
- W3101299715 cites W1593785499 @default.
- W3101299715 cites W1696206979 @default.
- W3101299715 cites W1889449076 @default.
- W3101299715 cites W1900752207 @default.
- W3101299715 cites W1945751328 @default.
- W3101299715 cites W1964906165 @default.
- W3101299715 cites W1965196441 @default.
- W3101299715 cites W1966133745 @default.
- W3101299715 cites W1967281437 @default.
- W3101299715 cites W1967735252 @default.
- W3101299715 cites W1970600816 @default.
- W3101299715 cites W1970852406 @default.
- W3101299715 cites W1975839888 @default.
- W3101299715 cites W1977430165 @default.
- W3101299715 cites W1979642301 @default.
- W3101299715 cites W1987998857 @default.
- W3101299715 cites W1989073099 @default.
- W3101299715 cites W1991182005 @default.
- W3101299715 cites W1992318166 @default.
- W3101299715 cites W1994139936 @default.
- W3101299715 cites W1995306046 @default.
- W3101299715 cites W1995923837 @default.
- W3101299715 cites W1998021006 @default.
- W3101299715 cites W2003968300 @default.
- W3101299715 cites W2004672082 @default.
- W3101299715 cites W2005001650 @default.
- W3101299715 cites W2006764302 @default.
- W3101299715 cites W2011259162 @default.
- W3101299715 cites W2015398597 @default.
- W3101299715 cites W2015650006 @default.
- W3101299715 cites W2019188215 @default.
- W3101299715 cites W2020825180 @default.
- W3101299715 cites W2021466019 @default.
- W3101299715 cites W202343169 @default.
- W3101299715 cites W2028900932 @default.
- W3101299715 cites W2028951205 @default.
- W3101299715 cites W2030021261 @default.
- W3101299715 cites W2036824041 @default.
- W3101299715 cites W2039181569 @default.
- W3101299715 cites W2040856930 @default.
- W3101299715 cites W2041036432 @default.
- W3101299715 cites W2041273498 @default.
- W3101299715 cites W2044573242 @default.
- W3101299715 cites W2049354054 @default.
- W3101299715 cites W2051992971 @default.
- W3101299715 cites W2052034283 @default.
- W3101299715 cites W2053805858 @default.
- W3101299715 cites W2057823239 @default.
- W3101299715 cites W2057905151 @default.
- W3101299715 cites W2060347702 @default.
- W3101299715 cites W2061517616 @default.
- W3101299715 cites W2061745435 @default.
- W3101299715 cites W2065788111 @default.
- W3101299715 cites W2065831703 @default.
- W3101299715 cites W2068728468 @default.
- W3101299715 cites W2070697863 @default.
- W3101299715 cites W2070810477 @default.
- W3101299715 cites W2078596607 @default.
- W3101299715 cites W2083994361 @default.
- W3101299715 cites W2084770788 @default.
- W3101299715 cites W2087282249 @default.
- W3101299715 cites W2087748457 @default.
- W3101299715 cites W2089016179 @default.
- W3101299715 cites W2095627608 @default.
- W3101299715 cites W2096597937 @default.
- W3101299715 cites W2099595170 @default.
- W3101299715 cites W2100987960 @default.
- W3101299715 cites W2101233587 @default.
- W3101299715 cites W2101643484 @default.
- W3101299715 cites W2103826070 @default.
- W3101299715 cites W2104816213 @default.
- W3101299715 cites W2105249237 @default.
- W3101299715 cites W2106232499 @default.
- W3101299715 cites W2107678707 @default.
- W3101299715 cites W2108579966 @default.
- W3101299715 cites W2112572641 @default.
- W3101299715 cites W2113097250 @default.
- W3101299715 cites W2113421289 @default.
- W3101299715 cites W2113961113 @default.
- W3101299715 cites W2115440397 @default.
- W3101299715 cites W2116562654 @default.
- W3101299715 cites W2117296341 @default.