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• W3101329573 abstract "Antidepressants and Major Depressive Disorder Selective-serotonin reuptake inhibitorsLuo L Wang & Raymond W LamLuo L WangLuo L Wang is a pharmacy student at the University of British Columbia, Vancouver, Canada and research assistant in the Mood Disorders Centre, University of British Columbia Hospital.Search for more papers by this author & Raymond W LamRaymond W Lam is Professor and Head of the Mood Disorders Program, Department of Psychiatry, University of British Columbia (Vancouver, Canada) and Director of the Mood Disorders Centre, University of British Columbia Hospital. He conducts clinical research in the psychobiology of mood disorders and clinical trials for pharmacologic and nonpharmacologic treatments in depression.Search for more papers by this authorPublished Online:27 Jun 2012https://doi.org/10.2217/ebo.11.385AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinkedInReddit View chapterAbstract: Selective-serotonin reuptake inhibitors are considered first-line antidepressants because of their safety, efficacy and tolerability, and are among the most widely prescribed medications for treating major depressive disorder. This chapter will review the available selective-serotonin reuptake inhibitors (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine and sertraline) with respect to comparative pharmacology, pharmacokinetics, efficacy, common and uncommon side-effect profiles, and drug safety. Special considerations in pregnancy, lactation, children and adolescents are also noted. References1 Anderson IM , Ferrier IN , Baldwin RC et al. Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2000 British Association for Psychopharmacology guidelines . J. Psychopharmacol. 22 , 343 – 396 (2008) . Crossref, Medline, CAS, Google Scholar2 American Psychiatric Association. Clinical practice guidelines for major depressive disorder. American Psychiatric Association, DC, USA (2011) . Google Scholar3 Lam RW , Kennedy SH , Grigoriadis S et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. III. Pharmacotherapy . J. Affect. Disord. 117 (Suppl 1) , S26 – S43 (2009) . Crossref, Medline, Google Scholar4 Chen F , Larsen MB , Sanchez C et al. 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Perinatol. 25 , 595 – 604 (2005) . Crossref, Medline, CAS, Google Scholar18 Hetrick SE , Merry SN , McKenzie J , Sindahl P , Proctor M . Selective serotonin reuptake inhibitors (SSRIs) for depressive disorders in children and adolescents . Cochrane Database Syst. Rev. 3 , CD004851 (2007) . Google Scholar19 Masi G , Liboni F , Brovedani P . Pharmacotherapy of major depressive disorder in adolescents . Expert Opin. Pharmacother. 11 (3) , 375 – 386 (2010) . Crossref, Medline, CAS, Google Scholar20 McEvoy GK (Ed.) . Antidepressants. In: American Hospital Formulary Service Drug Information, 2011 Edition. American Society of Health-System Pharmacists, Bethesda, MD, USA (2011) . Google Scholar21 Repchinksy C (Ed.) . Selective serotonin reuptake inhibitors (CPhA Monograph). In: Compendium of Pharmaceuticals and Specialties. Canadian Pharmacists Association Ottawa, Canada (2011) . Google ScholarWebsite101 US FDA: drug safety and availability. www.fda.gov/drugs/drugsafety/ucm269086.htm#sa.Google ScholarFiguresReferencesRelatedDetails Antidepressants and Major Depressive DisorderMetrics Downloaded 33 times History Published online 27 June 2012 Published in print June 2012 Information© Future Medicine Ltd© Future Medicine LtdPDF download" @default.
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