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- W3101348532 endingPage "116646" @default.
- W3101348532 startingPage "116646" @default.
- W3101348532 abstract "Microcystinase (MlrA) was first described in 1996. Since then MlrA peptidase activity has proven to be both the most efficient enzymatic process and the most specific catalyst of all known microcystins detoxification pathways. Furthermore, MlrA and the MlrABC degradation pathway are presently the only enzymatic processes with clear genetic and biochemical descriptions available for microcystins degradation, greatly facilitating modern applied genetics for any relevant technological development. Recently, there has been increasing interest in the potential of sustainable, biologically inspired alternatives to current industrial practice, with note that biological microcystins degradation is the primary detoxification process found in nature. While previous reviews have broadly discussed microbial biodegradation processes, here we present a review focused specifically on MlrA. Following a general overview, we briefly highlight the initial discovery and present understanding of the MlrABC degradation pathway, before discussing the genetic and biochemical aspects of MlrA. We then review the potential biotechnology applications of MlrA in the context of available literature with emphasis on the optimization of MlrA for in situ applications including (i) direct modulation of Mlr activity within naturally existing populations, (ii) bioaugmentation of systems with introduced biodegradative capacity via whole cell biocatalysts, and (iii) bioremediation via direct MlrA application." @default.
- W3101348532 created "2020-11-23" @default.
- W3101348532 creator A5003468589 @default.
- W3101348532 creator A5003782587 @default.
- W3101348532 creator A5034912092 @default.
- W3101348532 creator A5075543863 @default.
- W3101348532 date "2021-02-01" @default.
- W3101348532 modified "2023-10-10" @default.
- W3101348532 title "Microcystinase – a review of the natural occurrence, heterologous expression, and biotechnological application of MlrA" @default.
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