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- W3101431311 abstract "Abstract Late relapse of disseminated cancer cells is a common feature of some types of tumors. Several intrinsic and extrinsic factors have been shown to affect reawakening of disseminated dormant cancer cells (DDCCs); however, the signals and processes sustaining survival of DDCCs in a foreign environment are still poorly understood. We have recently shown that crosstalk with lung epithelial cells promotes persistence of DDCCs from estrogen receptor positive (ER+) breast tumors. Here we show that TFEB-lysosomal axis is activated in DDCCs and that it is modulated by the pro-survival ephrin receptor EphB6. TFEB lysosomal direct targets are enriched in DDCCs in vivo and correlate with relapse in ER+ breast cancer patients. Direct contact of DDCCs with alveolar type I-like lung epithelial cells drives lysosomal accumulation and EphB6 induction. EphB6 contributes to TFEB transcriptional activity and lysosome formation in DDCCs in vitro and in vivo , and supports survival of DDCCs in coculture and in vivo . Furthermore, signaling from EphB6 promotes the proliferative response of surrounding lung parenchymal cells in vivo ." @default.
- W3101431311 created "2020-11-23" @default.
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- W3101431311 date "2020-11-10" @default.
- W3101431311 modified "2023-10-18" @default.
- W3101431311 title "EphB6 regulates TFEB-lysosomal pathway and survival of disseminated quiescent breast cancer cells" @default.
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- W3101431311 doi "https://doi.org/10.1101/2020.11.10.376186" @default.
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