Matches in SemOpenAlex for { <https://semopenalex.org/work/W3101472981> ?p ?o ?g. }
- W3101472981 abstract "Abstract Parkinson's disease (PD) is a neurodegenerative disorder for which only symptomatic treatments are available. Repurposing drugs that target α-synuclein aggregation, considered one of the main drivers of PD progression, could accelerate the development of disease-modifying therapies. In this work, we focused on chemically modified tetracycline 3 (CMT-3), a derivative with reduced antibiotic activity that crosses the blood–brain barrier and is pharmacologically safe. We found that CMT-3 inhibited α-synuclein amyloid aggregation and led to the formation of non-toxic molecular species, unlike minocycline. Furthermore, CMT-3 disassembled preformed α-synuclein amyloid fibrils into smaller fragments that were unable to seed in subsequent aggregation reactions. Most interestingly, disaggregated species were non-toxic and less inflammogenic on brain microglial cells. Finally, we modelled the interactions between CMT-3 and α-synuclein aggregates by molecular simulations. In this way, we propose a mechanism for fibril disassembly. Our results place CMT-3 as a potential disease modifier for PD and possibly other synucleinopathies." @default.
- W3101472981 created "2020-11-23" @default.
- W3101472981 creator A5004955403 @default.
- W3101472981 creator A5012916724 @default.
- W3101472981 creator A5013327938 @default.
- W3101472981 creator A5014129850 @default.
- W3101472981 creator A5015111008 @default.
- W3101472981 creator A5042644787 @default.
- W3101472981 creator A5043907081 @default.
- W3101472981 creator A5058094517 @default.
- W3101472981 creator A5067145025 @default.
- W3101472981 creator A5076852851 @default.
- W3101472981 creator A5086981834 @default.
- W3101472981 date "2020-11-20" @default.
- W3101472981 modified "2023-10-18" @default.
- W3101472981 title "CMT-3 targets different α-synuclein aggregates mitigating their toxic and inflammogenic effects" @default.
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