Matches in SemOpenAlex for { <https://semopenalex.org/work/W3101473013> ?p ?o ?g. }
- W3101473013 abstract "ABSTRACT Only a subpopulation of non-small cell lung cancer (NSCLC) patients responds to immunotherapies, highlighting the urgent need to develop new therapeutic strategies to improve patient outcome. We developed a new chemical positive modulator (HEI3090) of the purinergic P2RX7 receptor that potentiates αPD-1 treatment to effectively control the growth of lung tumors in transplantable and oncogene-induced mouse models and triggers long lasting antitumor immune responses. Mechanistically, the molecule stimulates dendritic P2RX7 expressing cells to generate IL-18 which leads to the production of IFN-γ by Natural Killer and CD4 + T cells within tumors. Combined with immune checkpoint inhibitor, the molecule induces a complete tumor regression in 80% of LLC tumor bearing mice. Cured mice are also protected against tumor re-challenge due to a CD8-dependent protective response. Hence, combination treatment of small-molecule P2RX7 activator followed by immune checkpoint inhibitor represents a promising novel strategy that may be active against NSCLC." @default.
- W3101473013 created "2020-11-23" @default.
- W3101473013 creator A5010868189 @default.
- W3101473013 creator A5016441271 @default.
- W3101473013 creator A5024493210 @default.
- W3101473013 creator A5033164925 @default.
- W3101473013 creator A5039094119 @default.
- W3101473013 creator A5039731881 @default.
- W3101473013 creator A5041312764 @default.
- W3101473013 creator A5042393846 @default.
- W3101473013 creator A5042569929 @default.
- W3101473013 creator A5043621068 @default.
- W3101473013 creator A5046055163 @default.
- W3101473013 creator A5046633533 @default.
- W3101473013 creator A5046749913 @default.
- W3101473013 creator A5046876931 @default.
- W3101473013 creator A5056135125 @default.
- W3101473013 creator A5067704036 @default.
- W3101473013 creator A5084415045 @default.
- W3101473013 creator A5087545014 @default.
- W3101473013 creator A5089171072 @default.
- W3101473013 creator A5090515935 @default.
- W3101473013 date "2020-11-20" @default.
- W3101473013 modified "2023-10-17" @default.
- W3101473013 title "Small-molecule P2RX7 activator sensitizes tumor to immunotherapy and vaccinates mouse against tumor re-challenge" @default.
- W3101473013 cites W1442200272 @default.
- W3101473013 cites W1488069418 @default.
- W3101473013 cites W1905805852 @default.
- W3101473013 cites W1965553110 @default.
- W3101473013 cites W1980983174 @default.
- W3101473013 cites W1996145004 @default.
- W3101473013 cites W1996227994 @default.
- W3101473013 cites W2013617327 @default.
- W3101473013 cites W2027146979 @default.
- W3101473013 cites W2042906495 @default.
- W3101473013 cites W2058352883 @default.
- W3101473013 cites W2065150051 @default.
- W3101473013 cites W2072165205 @default.
- W3101473013 cites W2098005365 @default.
- W3101473013 cites W2119228184 @default.
- W3101473013 cites W2120390711 @default.
- W3101473013 cites W2129703772 @default.
- W3101473013 cites W2130153302 @default.
- W3101473013 cites W2137866616 @default.
- W3101473013 cites W2148085458 @default.
- W3101473013 cites W2165068298 @default.
- W3101473013 cites W2168269445 @default.
- W3101473013 cites W2297970549 @default.
- W3101473013 cites W2394893668 @default.
- W3101473013 cites W2530163240 @default.
- W3101473013 cites W2578528809 @default.
- W3101473013 cites W2585547361 @default.
- W3101473013 cites W2587048937 @default.
- W3101473013 cites W2765132620 @default.
- W3101473013 cites W2792040292 @default.
- W3101473013 cites W2810788886 @default.
- W3101473013 cites W2811413952 @default.
- W3101473013 cites W2883867232 @default.
- W3101473013 cites W2886489703 @default.
- W3101473013 cites W2904125616 @default.
- W3101473013 cites W2904564208 @default.
- W3101473013 cites W2917576966 @default.
- W3101473013 cites W2945715301 @default.
- W3101473013 cites W2946620901 @default.
- W3101473013 cites W2955029513 @default.
- W3101473013 cites W2957232260 @default.
- W3101473013 cites W2973638954 @default.
- W3101473013 cites W2986950076 @default.
- W3101473013 cites W2989801448 @default.
- W3101473013 cites W3037257919 @default.
- W3101473013 cites W3081642572 @default.
- W3101473013 doi "https://doi.org/10.1101/2020.11.19.388900" @default.
- W3101473013 hasPublicationYear "2020" @default.
- W3101473013 type Work @default.
- W3101473013 sameAs 3101473013 @default.
- W3101473013 citedByCount "0" @default.
- W3101473013 crossrefType "posted-content" @default.
- W3101473013 hasAuthorship W3101473013A5010868189 @default.
- W3101473013 hasAuthorship W3101473013A5016441271 @default.
- W3101473013 hasAuthorship W3101473013A5024493210 @default.
- W3101473013 hasAuthorship W3101473013A5033164925 @default.
- W3101473013 hasAuthorship W3101473013A5039094119 @default.
- W3101473013 hasAuthorship W3101473013A5039731881 @default.
- W3101473013 hasAuthorship W3101473013A5041312764 @default.
- W3101473013 hasAuthorship W3101473013A5042393846 @default.
- W3101473013 hasAuthorship W3101473013A5042569929 @default.
- W3101473013 hasAuthorship W3101473013A5043621068 @default.
- W3101473013 hasAuthorship W3101473013A5046055163 @default.
- W3101473013 hasAuthorship W3101473013A5046633533 @default.
- W3101473013 hasAuthorship W3101473013A5046749913 @default.
- W3101473013 hasAuthorship W3101473013A5046876931 @default.
- W3101473013 hasAuthorship W3101473013A5056135125 @default.
- W3101473013 hasAuthorship W3101473013A5067704036 @default.
- W3101473013 hasAuthorship W3101473013A5084415045 @default.
- W3101473013 hasAuthorship W3101473013A5087545014 @default.
- W3101473013 hasAuthorship W3101473013A5089171072 @default.
- W3101473013 hasAuthorship W3101473013A5090515935 @default.
- W3101473013 hasBestOaLocation W31014730131 @default.
- W3101473013 hasConcept C121608353 @default.
- W3101473013 hasConcept C126322002 @default.