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- W3101477057 endingPage "1142" @default.
- W3101477057 startingPage "1126" @default.
- W3101477057 abstract "It is widely accepted that the pathogen Clostridioides difficile exploits an intestinal environment with an altered microbiota, but the details of these microbe–microbe interactions are unclear. Adherence and colonization of mucus has been demonstrated for several enteric pathogens and it is possible that mucin-associated microbes may be working in concert with C. difficile. We showed that C. difficile ribotype-027 adheres to MUC2 glycans and using fecal bioreactors, we identified that C. difficile associates with several mucin-degrading microbes. C. difficile was found to chemotax toward intestinal mucus and its glycan components, demonstrating that C. difficile senses the mucus layer. Although C. difficile lacks the glycosyl hydrolases required to degrade mucin glycans, coculturing C. difficile with the mucin-degrading Akkermansia muciniphila, Bacteroides thetaiotaomicron, and Ruminococcus torques allowed C. difficile to grow in media that lacked glucose but contained purified MUC2. Collectively, these studies expand our knowledge on how intestinal microbes support C. difficile." @default.
- W3101477057 created "2020-11-23" @default.
- W3101477057 creator A5026484228 @default.
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- W3101477057 creator A5080092304 @default.
- W3101477057 date "2020-11-11" @default.
- W3101477057 modified "2023-10-14" @default.
- W3101477057 title "Mucin-Degrading Microbes Release Monosaccharides That Chemoattract <i>Clostridioides difficile</i> and Facilitate Colonization of the Human Intestinal Mucus Layer" @default.
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