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• W3101491087 endingPage "2472" @default.
• W3101491087 startingPage "2472" @default.
• W3101491087 abstract "Influenza viruses are a continual public health concern resulting in 3–5 million severe infections annually despite intense vaccination campaigns and messaging. Secondary bacterial infections, including Staphylococcus aureus, result in increased morbidity and mortality during seasonal epidemics and pandemics. While coinfections can result in deleterious pathologic consequences, including alveolar-capillary barrier disruption, the underlying mechanisms are poorly understood. We have characterized host- and pathogen-centric mechanisms contributing to influenza-bacterial coinfections in a primary cell coculture model of the alveolar-capillary barrier. Using 2009 pandemic influenza (pH1N1) and methicillin-resistant S. aureus (MRSA), we demonstrate that coinfection resulted in dysregulated barrier function. Preinfection with pH1N1 resulted in modulation of adhesion- and invasion-associated MRSA virulence factors during lag phase bacterial replication. Host response modulation in coinfected alveolar epithelial cells were primarily related to TLR- and inflammatory response-mediated cell signaling events. While less extensive in cocultured endothelial cells, coinfection resulted in changes to cellular stress response- and TLR-related signaling events. Analysis of cytokine expression suggested that cytokine secretion might play an important role in coinfection pathogenesis. Taken together, we demonstrate that coinfection pathogenesis is related to complex host- and pathogen-mediated events impacting both epithelial and endothelial cell regulation at the alveolar-capillary barrier." @default.
• W3101491087 created "2020-11-23" @default.
• W3101491087 creator A5005602641 @default.
• W3101491087 creator A5021278787 @default.
• W3101491087 creator A5026509479 @default.
• W3101491087 creator A5042286343 @default.
• W3101491087 date "2020-11-13" @default.
• W3101491087 modified "2023-09-25" @default.
• W3101491087 title "Dysregulated Host Responses Underlie 2009 Pandemic Influenza-Methicillin Resistant Staphylococcus aureus Coinfection Pathogenesis at the Alveolar-Capillary Barrier" @default.
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• W3101491087 doi "https://doi.org/10.3390/cells9112472" @default.
• W3101491087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7696554" @default.
• W3101491087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33202895" @default.
• W3101491087 hasPublicationYear "2020" @default.
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• W3101491087 hasAuthorship W3101491087A5005602641 @default.
• W3101491087 hasAuthorship W3101491087A5021278787 @default.
• W3101491087 hasAuthorship W3101491087A5026509479 @default.

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