Matches in SemOpenAlex for { <https://semopenalex.org/work/W3101540399> ?p ?o ?g. }
- W3101540399 endingPage "1743" @default.
- W3101540399 startingPage "1727" @default.
- W3101540399 abstract "Nucleic acids and proteins are shed into the bloodstream by tumor cells and can be exploited as biomarkers for the detection of cancer. In addition, cancer detection biomarkers can also be nontumor‐derived, having their origin in other organs and cell types. Hence, liquid biopsies provide a source of direct tumor cell‐derived biomolecules and indirect nontumor‐derived surrogate markers that circulate in body fluids or are taken up by circulating peripheral blood cells. The capacity of platelets to take up proteins and nucleic acids and alter their megakaryocyte‐derived transcripts and proteins in response to external signals makes them one of the richest liquid biopsy biosources. Platelets are the second most abundant cell type in peripheral blood and are routinely isolated through well‐established and fast methods in clinical diagnostics but their value as a source of cancer biomarkers is relatively recent. Platelets do not have a nucleus but have a functional spliceosome and protein translation machinery, to process RNA transcripts. Platelets emerge as important repositories of potential cancer biomarkers, including several types of RNAs (mRNA, miRNA, circRNA, lncRNA, and mitochondrial RNA) and proteins, and several preclinical studies have highlighted their potential as a liquid biopsy source for detecting various types and stages of cancer. Here, we address the usability of platelets as a liquid biopsy for the detection of cancer. We describe several studies that support the use of platelet biomarkers in cancer diagnostics and discuss what is still lacking for their implementation into the clinic." @default.
- W3101540399 created "2020-11-23" @default.
- W3101540399 creator A5009344649 @default.
- W3101540399 creator A5011911811 @default.
- W3101540399 creator A5053700204 @default.
- W3101540399 date "2020-12-14" @default.
- W3101540399 modified "2023-10-17" @default.
- W3101540399 title "Circulating platelets as liquid biopsy sources for cancer detection" @default.
- W3101540399 cites W168471380 @default.
- W3101540399 cites W1887762665 @default.
- W3101540399 cites W1966556597 @default.
- W3101540399 cites W1968519475 @default.
- W3101540399 cites W1972070926 @default.
- W3101540399 cites W1977991745 @default.
- W3101540399 cites W1982760718 @default.
- W3101540399 cites W1987370132 @default.
- W3101540399 cites W1992226521 @default.
- W3101540399 cites W1996765015 @default.
- W3101540399 cites W1997787147 @default.
- W3101540399 cites W2016741520 @default.
- W3101540399 cites W2018300054 @default.
- W3101540399 cites W2031336341 @default.
- W3101540399 cites W2035805526 @default.
- W3101540399 cites W2038475449 @default.
- W3101540399 cites W2042619042 @default.
- W3101540399 cites W2046509929 @default.
- W3101540399 cites W2047275955 @default.
- W3101540399 cites W2055313665 @default.
- W3101540399 cites W2055599313 @default.
- W3101540399 cites W2063446402 @default.
- W3101540399 cites W2068252527 @default.
- W3101540399 cites W2074892413 @default.
- W3101540399 cites W2076828545 @default.
- W3101540399 cites W2086746658 @default.
- W3101540399 cites W2088631979 @default.
- W3101540399 cites W2093440740 @default.
- W3101540399 cites W2097849024 @default.
- W3101540399 cites W2099521695 @default.
- W3101540399 cites W2107067281 @default.
- W3101540399 cites W2110430166 @default.
- W3101540399 cites W2112848779 @default.
- W3101540399 cites W2118688587 @default.
- W3101540399 cites W2119488140 @default.
- W3101540399 cites W2119764457 @default.
- W3101540399 cites W2134536161 @default.
- W3101540399 cites W2141569879 @default.
- W3101540399 cites W2152061559 @default.
- W3101540399 cites W2157820287 @default.
- W3101540399 cites W2163703314 @default.
- W3101540399 cites W2166771700 @default.
- W3101540399 cites W2314489585 @default.
- W3101540399 cites W2328494684 @default.
- W3101540399 cites W2395639552 @default.
- W3101540399 cites W2477339980 @default.
- W3101540399 cites W2520158723 @default.
- W3101540399 cites W2577474847 @default.
- W3101540399 cites W2578511153 @default.
- W3101540399 cites W2590954301 @default.
- W3101540399 cites W2593435710 @default.
- W3101540399 cites W2609501572 @default.
- W3101540399 cites W2614807349 @default.
- W3101540399 cites W2621272124 @default.
- W3101540399 cites W2749264889 @default.
- W3101540399 cites W2754669178 @default.
- W3101540399 cites W2754883020 @default.
- W3101540399 cites W2761458899 @default.
- W3101540399 cites W2762923518 @default.
- W3101540399 cites W2765301470 @default.
- W3101540399 cites W2783146090 @default.
- W3101540399 cites W2784116773 @default.
- W3101540399 cites W2789588291 @default.
- W3101540399 cites W2793969139 @default.
- W3101540399 cites W2800711883 @default.
- W3101540399 cites W2803857778 @default.
- W3101540399 cites W2808835040 @default.
- W3101540399 cites W2885430808 @default.
- W3101540399 cites W2899540665 @default.
- W3101540399 cites W2900018326 @default.
- W3101540399 cites W2900756811 @default.
- W3101540399 cites W2901354583 @default.
- W3101540399 cites W2904532826 @default.
- W3101540399 cites W2911546431 @default.
- W3101540399 cites W2914197968 @default.
- W3101540399 cites W2918755080 @default.
- W3101540399 cites W2922909127 @default.
- W3101540399 cites W2943263503 @default.
- W3101540399 cites W2943835743 @default.
- W3101540399 cites W2947060664 @default.
- W3101540399 cites W2949265339 @default.
- W3101540399 cites W2959920052 @default.
- W3101540399 cites W2961409389 @default.
- W3101540399 cites W2967804629 @default.
- W3101540399 cites W2976574309 @default.
- W3101540399 cites W2979255841 @default.
- W3101540399 cites W2984504036 @default.
- W3101540399 cites W2996072467 @default.
- W3101540399 cites W2998228994 @default.
- W3101540399 cites W3008503768 @default.