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• W3101716097 abstract "Abstract The COVID-19 pandemic has spread across more than 200 countries and resulted in over 170,000 deaths. For unclear reasons, higher mortality rates from COVID-19 have been reported in men compared to women. While the SARS-CoV-2 receptor ACE2 and serine protease TMPRSS2 have been detected in lung and other tissues, it is not clear what sex differences may exist. We analyzed a publicly-available normal human prostate single-cell RNA sequencing dataset and found TMPRSS2 and ACE2 co-expressing cells in epithelial cells, with a higher proportion in club and hillock cells. Then we investigated datasets of lung epithelial cells and also found club cells co-expressing TMPRSS2 and ACE2 . A comparison of ACE2 expression in lung tissue between males and females showed higher expression in males and a larger proportion of ACE2 + cells in male type II pneumocytes, with preliminary evidence that type II pneumocytes of all lung epithelial cell types showed the highest expression of ACE2 . These results raise the possibility that sex differences in ACE2 expression and the presence of double-positive cells in the prostate may contribute to the observed disparities of COVID-19." @default.
• W3101716097 created "2020-11-23" @default.
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• W3101716097 date "2020-04-25" @default.
• W3101716097 modified "2023-10-12" @default.
• W3101716097 title "Expression of <i>ACE2</i>, the SARS-CoV-2 receptor, and <i>TMPRSS2</i> in prostate epithelial cells" @default.
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• W3101716097 doi "https://doi.org/10.1101/2020.04.24.056259" @default.
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