FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3101777081> ?p ?o ?g. }

• W3101777081 endingPage "1194" @default.
• W3101777081 startingPage "1184" @default.
• W3101777081 abstract "Developing novel simple and ultrasensitive strategies for detecting microRNAs (miRNAs) is highly desirable because of their association with early cancer diagnostic and prognostic processes. Here a new chronocoulometric sensor, based on semiconducting 2H MoS2 nanosheets (MoS2 NSs) decorated with a controlled density of monodispersed small gold nanoparticles (AuNPs@MoS2), was fabricated via electrodeposition, for the highly sensitive detection of miRNA-21. The size and interparticle spacing of AuNPs were optimized by controlling nucleation and growth rates through the tuning of deposition potential and Au precursor concentration and by getting simultaneous feedback from morphological and electrochemical activity studies. The sensing strategy, involved the selective immobilization of the thiolated capture probe DNA (CP) at AuNPs and hybridization of CP to a part of the miRNA target, whereas the remaining part of the target was complementary to a signaling nonlabeled DNA sequence that served to amplify the target upon hybridization. Chronocoulometry provided precise quantification of nucleic acids at each step of the sensor assay by interrogating [Ru(NH3)6]3+ electrostatically bound to phosphate backbones of oligonucleotides. A detailed and systematic optimization study demonstrated that the thinnest and smallest MoS2 NSs improved the sensitivity of the AuNP@MoS2 sensor, achieving an impressive detection limit of ≈100 aM, which is 2 orders of magnitude lower than that of a bare Au electrode and also enhanced the DNA–miRNA hybridization efficiency by 25%. Such an improved performance can be attributed to the controlled packing density of CPs achieved by their self-assembly on AuNPs, large interparticle density, small size, and intimate coupling between AuNPs and MoS2. Alongside the outstanding sensitivity, the sensor exhibited an excellent selectivity down to femtomolar concentrations, for discriminating a complementary miRNA-21 target in a complex system composed of different foreign targets including mismatched and noncomplementary miRNA-155. These advantages make our sensor a promising contender in the point of care miRNA sensor family for medical diagnostics." @default.
• W3101777081 created "2020-11-23" @default.
• W3101777081 creator A5055763793 @default.
• W3101777081 creator A5057381948 @default.
• W3101777081 creator A5075601266 @default.
• W3101777081 date "2018-09-10" @default.
• W3101777081 modified "2023-09-27" @default.
• W3101777081 title "Sensitive Chronocoulometric Detection of miRNA at Screen-Printed Electrodes Modified by Gold-Decorated MoS₂ Nanosheets" @default.
• W3101777081 cites W1500686487 @default.
• W3101777081 cites W1672385484 @default.
• W3101777081 cites W1982883071 @default.
• W3101777081 cites W1985297485 @default.
• W3101777081 cites W1991545630 @default.
• W3101777081 cites W1991875973 @default.
• W3101777081 cites W1997577546 @default.
• W3101777081 cites W2000500676 @default.
• W3101777081 cites W2017132242 @default.
• W3101777081 cites W2017677233 @default.
• W3101777081 cites W2021502188 @default.
• W3101777081 cites W2022997694 @default.
• W3101777081 cites W2046423451 @default.
• W3101777081 cites W2053562295 @default.
• W3101777081 cites W2058828522 @default.
• W3101777081 cites W2060708522 @default.
• W3101777081 cites W2080272020 @default.
• W3101777081 cites W2094683520 @default.
• W3101777081 cites W2103437569 @default.
• W3101777081 cites W2105268405 @default.
• W3101777081 cites W2105760193 @default.
• W3101777081 cites W2126174029 @default.
• W3101777081 cites W2129154422 @default.
• W3101777081 cites W2152458169 @default.
• W3101777081 cites W2304360524 @default.
• W3101777081 cites W2346180058 @default.
• W3101777081 cites W2469523123 @default.
• W3101777081 cites W2516488242 @default.
• W3101777081 cites W2523274166 @default.
• W3101777081 cites W2532161633 @default.
• W3101777081 cites W2570195629 @default.
• W3101777081 cites W2575110432 @default.
• W3101777081 cites W2583368323 @default.
• W3101777081 cites W2588965304 @default.
• W3101777081 cites W2591819714 @default.
• W3101777081 cites W2595004454 @default.
• W3101777081 cites W2735268749 @default.
• W3101777081 cites W2754502717 @default.
• W3101777081 cites W2760359627 @default.
• W3101777081 cites W2772415314 @default.
• W3101777081 cites W2773690449 @default.
• W3101777081 cites W2779866959 @default.
• W3101777081 cites W4377077042 @default.
• W3101777081 doi "https://doi.org/10.1021/acsabm.8b00398" @default.
• W3101777081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34996159" @default.
• W3101777081 hasPublicationYear "2018" @default.
• W3101777081 type Work @default.
• W3101777081 sameAs 3101777081 @default.
• W3101777081 citedByCount "32" @default.
• W3101777081 countsByYear W31017770812019 @default.
• W3101777081 countsByYear W31017770812020 @default.
• W3101777081 countsByYear W31017770812021 @default.
• W3101777081 countsByYear W31017770812022 @default.
• W3101777081 countsByYear W31017770812023 @default.
• W3101777081 crossrefType "journal-article" @default.
• W3101777081 hasAuthorship W3101777081A5055763793 @default.
• W3101777081 hasAuthorship W3101777081A5057381948 @default.
• W3101777081 hasAuthorship W3101777081A5075601266 @default.
• W3101777081 hasBestOaLocation W31017770812 @default.
• W3101777081 hasConcept C104819515 @default.
• W3101777081 hasConcept C119128265 @default.
• W3101777081 hasConcept C129312508 @default.
• W3101777081 hasConcept C147789679 @default.
• W3101777081 hasConcept C155672457 @default.
• W3101777081 hasConcept C160756335 @default.
• W3101777081 hasConcept C171250308 @default.
• W3101777081 hasConcept C17525397 @default.
• W3101777081 hasConcept C178790620 @default.
• W3101777081 hasConcept C185592680 @default.
• W3101777081 hasConcept C192562407 @default.
• W3101777081 hasConcept C21951064 @default.
• W3101777081 hasConcept C2910973916 @default.
• W3101777081 hasConcept C43617362 @default.
• W3101777081 hasConcept C49040817 @default.
• W3101777081 hasConcept C52859227 @default.
• W3101777081 hasConcept C552990157 @default.
• W3101777081 hasConcept C55493867 @default.
• W3101777081 hasConcept C61048295 @default.
• W3101777081 hasConceptScore W3101777081C104819515 @default.
• W3101777081 hasConceptScore W3101777081C119128265 @default.
• W3101777081 hasConceptScore W3101777081C129312508 @default.
• W3101777081 hasConceptScore W3101777081C147789679 @default.
• W3101777081 hasConceptScore W3101777081C155672457 @default.
• W3101777081 hasConceptScore W3101777081C160756335 @default.
• W3101777081 hasConceptScore W3101777081C171250308 @default.
• W3101777081 hasConceptScore W3101777081C17525397 @default.
• W3101777081 hasConceptScore W3101777081C178790620 @default.
• W3101777081 hasConceptScore W3101777081C185592680 @default.
• W3101777081 hasConceptScore W3101777081C192562407 @default.
• W3101777081 hasConceptScore W3101777081C21951064 @default.

• next