Matches in SemOpenAlex for { <https://semopenalex.org/work/W3101800945> ?p ?o ?g. }
- W3101800945 abstract "ABSTRACT Thalamocortical neurons (TCNs) transmit information about sensory stimuli from the thalamus to the cortex. In response to different physiological states and demands TCNs can fire in tonic and/or phasic burst modes. These firing properties of TCNs are supported by precisely timed inhibitory synaptic inputs from the thalamic reticular nucleus and intrinsic currents, including T-type Ca 2+ and HCN currents. These intrinsic currents are mediated by Cav3.1 and HCN channel subunits, and alterations in expression or modulation of these channels can have dramatic implications on thalamus function. The factors that regulate these currents controlling the firing patterns important for integration of the sensory stimuli and the consequences resulting from the disruption of these firing patterns are not well understood. Shox2 is a transcription factor known to be important for pacemaker activity in the heart. We show here that Shox2 is also expressed in adult mouse thalamus. We hypothesized that genes regulated by Shox2’s transcriptional activity may be important for physiological properties of TCNs. In this study, we used RNA sequencing on control and Shox2 knockout mice to determine Shox2 -affected genes and revealed a network of ion channel genes important for neuronal firing properties. Quantitative PCR confirmed that expression of Hcn 2, 4 and Cav3 . 1 genes were affected by Shox2 KO. Western blotting showed expression of the proteins for these channels was decreased in the thalamus, and electrophysiological recordings showed that Shox2 KO impacted the firing and synaptic properties of TCNs. Finally, behavioral studies revealed that Shox2 expression in TCNs play a role in somatosensory function and object recognition memory. Overall, these results reveal Shox2 as a transcription factor important for TCN firing properties and thalamic function." @default.
- W3101800945 created "2020-11-23" @default.
- W3101800945 creator A5008577248 @default.
- W3101800945 creator A5018893920 @default.
- W3101800945 creator A5033786648 @default.
- W3101800945 creator A5044970947 @default.
- W3101800945 creator A5050455404 @default.
- W3101800945 creator A5054017145 @default.
- W3101800945 creator A5055977442 @default.
- W3101800945 creator A5061267326 @default.
- W3101800945 creator A5065401434 @default.
- W3101800945 creator A5081106773 @default.
- W3101800945 creator A5081597052 @default.
- W3101800945 creator A5083349761 @default.
- W3101800945 date "2019-06-05" @default.
- W3101800945 modified "2023-09-27" @default.
- W3101800945 title "The transcription factor Shox2 shapes thalamocortical neuron firing and synaptic properties" @default.
- W3101800945 cites W1196426961 @default.
- W3101800945 cites W1496642521 @default.
- W3101800945 cites W1502703412 @default.
- W3101800945 cites W1543138196 @default.
- W3101800945 cites W1567550846 @default.
- W3101800945 cites W1573726161 @default.
- W3101800945 cites W1578017152 @default.
- W3101800945 cites W1748089690 @default.
- W3101800945 cites W1753443034 @default.
- W3101800945 cites W1768274470 @default.
- W3101800945 cites W1845250825 @default.
- W3101800945 cites W1850046002 @default.
- W3101800945 cites W1871288837 @default.
- W3101800945 cites W1886588869 @default.
- W3101800945 cites W1967764121 @default.
- W3101800945 cites W1974942348 @default.
- W3101800945 cites W1976059901 @default.
- W3101800945 cites W1978925023 @default.
- W3101800945 cites W1979975126 @default.
- W3101800945 cites W1981348384 @default.
- W3101800945 cites W1981788229 @default.
- W3101800945 cites W1984310913 @default.
- W3101800945 cites W1993391356 @default.
- W3101800945 cites W1996849853 @default.
- W3101800945 cites W1997309908 @default.
- W3101800945 cites W1999515062 @default.
- W3101800945 cites W2002532606 @default.
- W3101800945 cites W2003143758 @default.
- W3101800945 cites W2003966687 @default.
- W3101800945 cites W2004238936 @default.
- W3101800945 cites W2007502604 @default.
- W3101800945 cites W2011601662 @default.
- W3101800945 cites W2012794977 @default.
- W3101800945 cites W2013184477 @default.
- W3101800945 cites W2014880992 @default.
- W3101800945 cites W2025500109 @default.
- W3101800945 cites W2025655242 @default.
- W3101800945 cites W2026823182 @default.
- W3101800945 cites W2030076281 @default.
- W3101800945 cites W2036101990 @default.
- W3101800945 cites W2041360032 @default.
- W3101800945 cites W2042036678 @default.
- W3101800945 cites W2047857929 @default.
- W3101800945 cites W2048160857 @default.
- W3101800945 cites W2048760173 @default.
- W3101800945 cites W2050646342 @default.
- W3101800945 cites W2055352878 @default.
- W3101800945 cites W2061314910 @default.
- W3101800945 cites W2064015155 @default.
- W3101800945 cites W2066556421 @default.
- W3101800945 cites W2067699039 @default.
- W3101800945 cites W2072632446 @default.
- W3101800945 cites W2073658789 @default.
- W3101800945 cites W2076927652 @default.
- W3101800945 cites W2079660315 @default.
- W3101800945 cites W2082555121 @default.
- W3101800945 cites W2087818666 @default.
- W3101800945 cites W2091368561 @default.
- W3101800945 cites W2092305394 @default.
- W3101800945 cites W2095519131 @default.
- W3101800945 cites W2095778232 @default.
- W3101800945 cites W2101024728 @default.
- W3101800945 cites W2102138781 @default.
- W3101800945 cites W2103300068 @default.
- W3101800945 cites W2103397222 @default.
- W3101800945 cites W2107569547 @default.
- W3101800945 cites W2110285260 @default.
- W3101800945 cites W2112106852 @default.
- W3101800945 cites W2114784445 @default.
- W3101800945 cites W2120836623 @default.
- W3101800945 cites W2121202965 @default.
- W3101800945 cites W2121927821 @default.
- W3101800945 cites W2123713348 @default.
- W3101800945 cites W2123729556 @default.
- W3101800945 cites W2133465414 @default.
- W3101800945 cites W2137303544 @default.
- W3101800945 cites W2144063270 @default.
- W3101800945 cites W2145117823 @default.
- W3101800945 cites W2145742025 @default.
- W3101800945 cites W2151903421 @default.
- W3101800945 cites W2152691873 @default.
- W3101800945 cites W2155344424 @default.
- W3101800945 cites W2156759341 @default.