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• W3101811728 abstract "Despite ground-breaking innovations for most autoimmune diseases, the treatment of lupus nephritis has remained largely the same for decades because none of the tested drugs demonstrated superiority over standard-of-care in randomized controlled clinical trials.Recently, the Belimumab in Subjects with Systemic Lupus Erythematosus - Lupus Nephritis trial tested belimumab, an inhibitor of B-cell activating factor, as an add-on therapy to steroids and either mycophenolate mofetil (MMF) or cyclophosphamide when given IV monthly over a period of 104 weeks at an effect size of 11% for a Primary Efficacy Renal Response. The NOBILITY trial reported positive results for the B-cell-depleting agent obinutuzumab as an add-on therapy to steroids and MMF when given IV every 6 months over a period of 76 weeks at an effect size of 22% for a complete renal response (CRR). The AURORA trial reported positive results for the calcineurin inhibitor voclosporin as an oral add-on therapy to low dose steroids and MMF when given twice daily over a period of 52 weeks at an effect size of 18.5% for a CRR.These studies will change the treatment landscape of lupus nephritis. In which way is discussed in this article." @default.
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• W3101811728 date "2020-11-12" @default.
• W3101811728 modified "2023-09-26" @default.
• W3101811728 title "B-cell depletion or belimumab or voclosporin for lupus nephritis?" @default.
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• W3101811728 doi "https://doi.org/10.1097/mnh.0000000000000662" @default.
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