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- W3101833129 abstract "Quorum sensing (QS) defines the underlying mechanism of microbial interactions within different climates. It controls the microbial proliferation at the microcosmic level and plays a quintessential role in their biofilm formation ability. To block the deteriorating aspects of microbial biofilms, the disruption of the QS mechanism is essential. Contrary to this, biofilm formation should get induced to supplement the leguminous plant growth. Such extreme targets could be achieved by modulating the underlying channels of the signal molecules influencing the QS mechanism. Desired modification in the signal and strength of QS mechanisms could be attained via editing the genetic material of the model organism. Although conventional genome editing techniques offer an array of opportunities, cumbersome validation, and limited efficiency restricts their applications. Therefore, a robust, transformative, and efficient approach is required to introduce the desired modification in the genome within a short time duration. The recent techniques, e.g., CRISPR, offer promising avenues to fill the operational limitations that still exist with conventional approaches. Therefore, a critical overview is drafted on the role and applications offered by the different subtypes of the CRISPR approach for modulating the signaling pattern of QS in microbes. Likewise, a detailed description is given on the various tools which are essential for designing the working methodology for the CRISPR approach." @default.
- W3101833129 created "2020-11-23" @default.
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- W3101833129 date "2020-01-01" @default.
- W3101833129 modified "2023-10-18" @default.
- W3101833129 title "Role of the CRISPR Technique in Decoding the Principles of Quorum Sensing" @default.
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- W3101833129 doi "https://doi.org/10.1021/bk-2020-1374.ch004" @default.
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