Matches in SemOpenAlex for { <https://semopenalex.org/work/W3101861594> ?p ?o ?g. }
- W3101861594 endingPage "420" @default.
- W3101861594 startingPage "373" @default.
- W3101861594 abstract "In the last decades, surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) has attracted increasing interest due to its unique capabilities, achievable through the nanostructured substrates used to promote the analyte desorption/ionization. While the most widely recognized asset of SALDI-MS is the untargeted analysis of small molecules, this technique also offers the possibility of targeted approaches. In particular, the implementation of SALDI-MS imaging (SALDI-MSI), which is the focus of this review, opens up new opportunities. After a brief discussion of the nomenclature and the fundamental mechanisms associated with this technique, which are still highly controversial, the analytical strategies to perform SALDI-MSI are extensively discussed. Emphasis is placed on the sample preparation but also on the selection of the nanosubstrate (in terms of chemical composition and morphology) as well as its functionalization possibilities for the selective analysis of specific compounds in targeted approaches. Subsequently, some selected applications of SALDI-MSI in various fields (i.e., biomedical, biological, environmental, and forensic) are presented. The strengths and the remaining limitations of SALDI-MSI are finally summarized in the conclusion and some perspectives of this technique, which has a bright future, are proposed in this section." @default.
- W3101861594 created "2020-11-23" @default.
- W3101861594 creator A5010369940 @default.
- W3101861594 creator A5024817523 @default.
- W3101861594 creator A5028240827 @default.
- W3101861594 creator A5036515409 @default.
- W3101861594 creator A5066187683 @default.
- W3101861594 date "2020-11-10" @default.
- W3101861594 modified "2023-10-14" @default.
- W3101861594 title "Surface‐assisted laser desorption/ionization mass spectrometry imaging: A review" @default.
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