Matches in SemOpenAlex for { <https://semopenalex.org/work/W3101872404> ?p ?o ?g. }
- W3101872404 endingPage "73" @default.
- W3101872404 startingPage "63" @default.
- W3101872404 abstract "Introduction : Cardiac fibrosis contributes to the development of cardiovascular disease (CVD) and arrhythmia. Cardiac fibroblasts (CFs) are collagen-producing cells that regulate extracellular matrix (ECM) homeostasis. A complex signaling network has been defined linking environmental stress to changes in CF function and fibrosis. Signal Transducer and Activator of Transcription 3 (STAT3) has emerged as a critical integrator of pro-fibrotic signals in CFs downstream of several established signaling networks. Areas covered : This article provides an overview of STAT3 function in CFs and its involvement in coordinating a vast web of intracellular pro-fibrotic signaling molecules and transcription factors. We highlight recent work elucidating a critical role for the fibroblast cytoskeleton in maintaining spatial and temporal control of STAT3-related signaling . Finally, we discuss potential opportunities and obstacles for therapeutic targeting of STAT3 to modulate cardiac fibrosis and arrhythmias. Relevant publications on the topic were identified through Pubmed. Expert opinion : Therapeutic targeting of STAT3 for CVD and arrhythmias presents unique challenges and opportunities. Thus, it is critical to consider the multimodal and dynamic nature of STAT3 signaling. Going forward, it will be beneficial to consider ways to maintain balanced STAT3 function, rather than large-scale perturbations in STAT3 function." @default.
- W3101872404 created "2020-11-23" @default.
- W3101872404 creator A5000763054 @default.
- W3101872404 creator A5021749666 @default.
- W3101872404 creator A5023812142 @default.
- W3101872404 creator A5065702246 @default.
- W3101872404 date "2020-11-23" @default.
- W3101872404 modified "2023-10-12" @default.
- W3101872404 title "Emerging therapeutic targets for cardiac arrhythmias: role of STAT3 in regulating cardiac fibroblast function" @default.
- W3101872404 cites W1483896637 @default.
- W3101872404 cites W1633357948 @default.
- W3101872404 cites W174882102 @default.
- W3101872404 cites W1879729745 @default.
- W3101872404 cites W1913262543 @default.
- W3101872404 cites W1967959755 @default.
- W3101872404 cites W1970190279 @default.
- W3101872404 cites W1975318062 @default.
- W3101872404 cites W1978966324 @default.
- W3101872404 cites W1979992454 @default.
- W3101872404 cites W1980817114 @default.
- W3101872404 cites W1983554746 @default.
- W3101872404 cites W1989610794 @default.
- W3101872404 cites W1993569315 @default.
- W3101872404 cites W1997282845 @default.
- W3101872404 cites W1999661963 @default.
- W3101872404 cites W2001517178 @default.
- W3101872404 cites W2006245789 @default.
- W3101872404 cites W2008635369 @default.
- W3101872404 cites W2011011942 @default.
- W3101872404 cites W2018252938 @default.
- W3101872404 cites W2020858778 @default.
- W3101872404 cites W2022846817 @default.
- W3101872404 cites W2029567799 @default.
- W3101872404 cites W2033862525 @default.
- W3101872404 cites W2040148968 @default.
- W3101872404 cites W2042503285 @default.
- W3101872404 cites W2050712486 @default.
- W3101872404 cites W2050862994 @default.
- W3101872404 cites W2053595149 @default.
- W3101872404 cites W2061058076 @default.
- W3101872404 cites W2065566303 @default.
- W3101872404 cites W2066885817 @default.
- W3101872404 cites W2078516286 @default.
- W3101872404 cites W2079761398 @default.
- W3101872404 cites W2082301583 @default.
- W3101872404 cites W2082323241 @default.
- W3101872404 cites W2090392605 @default.
- W3101872404 cites W2101244168 @default.
- W3101872404 cites W2103422355 @default.
- W3101872404 cites W2104783592 @default.
- W3101872404 cites W2106618944 @default.
- W3101872404 cites W2111484951 @default.
- W3101872404 cites W2116815871 @default.
- W3101872404 cites W2118789629 @default.
- W3101872404 cites W2120338621 @default.
- W3101872404 cites W2121701455 @default.
- W3101872404 cites W2122401199 @default.
- W3101872404 cites W2128577198 @default.
- W3101872404 cites W2131255875 @default.
- W3101872404 cites W2134931198 @default.
- W3101872404 cites W2135576636 @default.
- W3101872404 cites W2145067395 @default.
- W3101872404 cites W2146434832 @default.
- W3101872404 cites W2148627289 @default.
- W3101872404 cites W2149070581 @default.
- W3101872404 cites W2149179723 @default.
- W3101872404 cites W2151406417 @default.
- W3101872404 cites W2160579895 @default.
- W3101872404 cites W2168072233 @default.
- W3101872404 cites W2172237567 @default.
- W3101872404 cites W2180493842 @default.
- W3101872404 cites W2214775869 @default.
- W3101872404 cites W2299099463 @default.
- W3101872404 cites W2303587096 @default.
- W3101872404 cites W2341868068 @default.
- W3101872404 cites W2346339755 @default.
- W3101872404 cites W2406860897 @default.
- W3101872404 cites W2415591668 @default.
- W3101872404 cites W2462505067 @default.
- W3101872404 cites W2471131657 @default.
- W3101872404 cites W2562492920 @default.
- W3101872404 cites W2585368532 @default.
- W3101872404 cites W2608644283 @default.
- W3101872404 cites W2737236341 @default.
- W3101872404 cites W2750808153 @default.
- W3101872404 cites W2751220340 @default.
- W3101872404 cites W2755990808 @default.
- W3101872404 cites W2756797982 @default.
- W3101872404 cites W2766965802 @default.
- W3101872404 cites W2776145532 @default.
- W3101872404 cites W2782415666 @default.
- W3101872404 cites W2800350399 @default.
- W3101872404 cites W2801530055 @default.
- W3101872404 cites W2809022782 @default.
- W3101872404 cites W2886980930 @default.
- W3101872404 cites W2887191177 @default.
- W3101872404 cites W2891718328 @default.
- W3101872404 cites W2901491632 @default.