Matches in SemOpenAlex for { <https://semopenalex.org/work/W3101903670> ?p ?o ?g. }
Showing items 1 to 50 of
50
with 100 items per page.
- W3101903670 abstract "The plant Mitragyna speciosa Korth, is receiving increased attention as a therapeutic substitution for opioid use disorder (OUD). The active alkaloids constituents of the plant, particularly mitragynine and 7-hydroxymitragynine, have been shown to modulate opioid receptors, acting as agonists at mu-opioid receptors. Given this pharmacology, several studies have examined the abuse and dependence potential of Mitragyna speciosa and its alkaloids in various animal models of dependence. In addition to action on opioid receptors, the mitragyna alkaloids also appear to exert diverse activities at other receptors in the central nervous system (CNS) which may explain the complex pharmacological profile of these alkaloids. Hence, this review aims to provide an overview of the preclinical studies used to study Mitragyna speciosa dependence potential and describe recent progress made in assessing whether the plant or its active alkaloids can offer alternatives to opioids in management of OUD. In conclusion, Mitragyna speciosa Korth or its compound mitragynine may offer alternatives as a replacement therapy to opioid. :TJPS-2020-0129.R1" @default.
- W3101903670 created "2020-11-23" @default.
- W3101903670 creator A5025720471 @default.
- W3101903670 creator A5029172157 @default.
- W3101903670 creator A5037401487 @default.
- W3101903670 creator A5053985774 @default.
- W3101903670 creator A5078146772 @default.
- W3101903670 creator A5079797792 @default.
- W3101903670 date "2021-06-29" @default.
- W3101903670 modified "2023-09-28" @default.
- W3101903670 title "Current Perspectives on the Therapeutic Potential of Mitragyna Speciosa and Its Derivatives on Animal Model:(TJPS-2020-0129.R1)" @default.
- W3101903670 hasPublicationYear "2021" @default.
- W3101903670 type Work @default.
- W3101903670 sameAs 3101903670 @default.
- W3101903670 citedByCount "0" @default.
- W3101903670 crossrefType "journal-article" @default.
- W3101903670 hasAuthorship W3101903670A5025720471 @default.
- W3101903670 hasAuthorship W3101903670A5029172157 @default.
- W3101903670 hasAuthorship W3101903670A5037401487 @default.
- W3101903670 hasAuthorship W3101903670A5053985774 @default.
- W3101903670 hasAuthorship W3101903670A5078146772 @default.
- W3101903670 hasAuthorship W3101903670A5079797792 @default.
- W3101903670 hasConcept C126322002 @default.
- W3101903670 hasConcept C170493617 @default.
- W3101903670 hasConcept C2781063702 @default.
- W3101903670 hasConcept C71924100 @default.
- W3101903670 hasConcept C98274493 @default.
- W3101903670 hasConceptScore W3101903670C126322002 @default.
- W3101903670 hasConceptScore W3101903670C170493617 @default.
- W3101903670 hasConceptScore W3101903670C2781063702 @default.
- W3101903670 hasConceptScore W3101903670C71924100 @default.
- W3101903670 hasConceptScore W3101903670C98274493 @default.
- W3101903670 hasIssue "3" @default.
- W3101903670 hasLocation W31019036701 @default.
- W3101903670 hasOpenAccess W3101903670 @default.
- W3101903670 hasPrimaryLocation W31019036701 @default.
- W3101903670 hasRelatedWork W1608767677 @default.
- W3101903670 hasRelatedWork W193406161 @default.
- W3101903670 hasRelatedWork W2103721605 @default.
- W3101903670 hasRelatedWork W2157788290 @default.
- W3101903670 hasRelatedWork W2408630155 @default.
- W3101903670 hasRelatedWork W3049521994 @default.
- W3101903670 hasRelatedWork W3106786641 @default.
- W3101903670 hasRelatedWork W3176973669 @default.
- W3101903670 hasRelatedWork W2186692913 @default.
- W3101903670 hasVolume "45" @default.
- W3101903670 isParatext "false" @default.
- W3101903670 isRetracted "false" @default.
- W3101903670 magId "3101903670" @default.
- W3101903670 workType "article" @default.