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• W3101928411 endingPage "8697" @default.
• W3101928411 startingPage "8697" @default.
• W3101928411 abstract "Canine mammary tumors (CMT) constitute the most common tumor types found in female dogs. Understanding this cancer through extensive research is important not only for clinical veterinary applications, but also in the scope of comparative oncology. The use of DNA methylation as a biomarker has been noted for numerous cancers in the form of both tissue and liquid biopsies, yet the study of methylation in CMT has been limited. By analyzing our canine methyl-binding domain sequencing (MBD-seq) data, we identified intron regions of canine ANK2 and EPAS1 as differentially methylated regions (DMGs) in CMT. Subsequently, we established quantitative methylation specific PCR (qMSP) of ANK2 and EPAS1 to validate the target hypermethylation in CMT tissue, as well as cell free DNA (cfDNA) from CMT plasma. Both ANK2 and EPAS1 were hypermethylated in CMT and highlighted as potential tissue biomarkers in CMT. ANK2 additionally showed significant hypermethylation in the plasma cfDNA of CMT, indicating that it could be a potential liquid biopsy biomarker as well. A similar trend towards hypermethylation was indicated in HBC at a specific CpG of the ANK2 target on the orthologous human region, which validates the comparative approach using aberrant methylation in CMT." @default.
• W3101928411 created "2020-11-23" @default.
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• W3101928411 date "2020-11-18" @default.
• W3101928411 modified "2023-09-26" @default.
• W3101928411 title "ANK2 Hypermethylation in Canine Mammary Tumors and Human Breast Cancer" @default.
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• W3101928411 doi "https://doi.org/10.3390/ijms21228697" @default.
• W3101928411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7698701" @default.
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• W3101928411 hasPublicationYear "2020" @default.
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