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• W3101930079 endingPage "100831" @default.
• W3101930079 startingPage "100831" @default.
• W3101930079 abstract "In late December 2019, several cases of pneumonia of unknown etiology (COVID-19) were reported in Wuhan, Hubei province, China. Based on clinical findings, blood tests and chest radiographs, this disease was diagnosed as a virus-associated pneumonia. Sequence analysis revealed a novel coronavirus, called SARS-CoV-2 (formerly called 2019-nCoV), as the causative agent of pneumonia of unknown etiology. So far, the SARS-CoV-2 infection continues to spread, and this virus poses a serious public health threat. In this study, it was aimed to reveal potential miRNA targets for the regulation of SARS-CoV-2 host cell receptor ACE2. For the identification of potential miRNA targets for the ACE2 gene, TarBase v.8 (DIANA Tools), TargetScan, miRTarBase and miRDB miRNA-target prediction algorithms were used. FANTOM5 CAGE was used for the cellular ontology analysis. Expression levels of these miRNAs were determined using OncomiR Pan-Cancer miRNome Atlas. The results suggest that members of miR-200 family of miRNAs, especially miR-200c-3p, are strong candidate targets for the regulation of ACE2 in respiratory system cells. Consequently, the present study for the first time emphasizes potential use of miRNA-based therapeutics in the battle against SARS-CoV-2 infection and its deadly disease, COVID-19." @default.
• W3101930079 created "2020-11-23" @default.
• W3101930079 creator A5063378973 @default.
• W3101930079 date "2021-02-01" @default.
• W3101930079 modified "2023-10-16" @default.
• W3101930079 title "Therapeutic potential of miRNAs targeting SARS-CoV-2 host cell receptor ACE2" @default.
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• W3101930079 doi "https://doi.org/10.1016/j.mgene.2020.100831" @default.
• W3101930079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7672338" @default.
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