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• W3102011969 abstract "Abstract Hexarelin, a synthetic hexapeptide, protects cardiac and skeletal muscles by inhibiting apoptosis, both in vitro and in vivo . Moreover, evidence suggests that hexarelin could have important neuroprotective bioactivity. Oxidative stress and the generation of free radicals has been implicated in the etiologies of several neurodegenerative diseases, including amyotrophic lateral sclerosis, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease and multiple sclerosis. In addition to direct oxidative stress, exogenous hydrogen peroxide (H 2 O 2 ) can penetrate biological membranes and enhance the formation of other reactive oxygen species. The aim of this study was to examine the inhibitory influence of hexarelin on H 2 O 2 -induced apoptosis in Neuro-2A cells, a mouse neuroblastoma cell line. Our results indicate that H 2 O 2 reduced the viability of Neuro-2A cells in a dose-related fashion. Furthermore, H 2 O 2 induced significant changes in the morphology of Neuro-2A cells, reflected in the formation of apoptotic cell bodies, and an increase of nitric oxide (NO) production. Hexarelin effectively antagonized H 2 O 2 oxidative damage to Neuro-2A cells as indicated by improved cell viability, normal morphology and reduced nitrite (NO 2 − ) release. Hexarelin treatment of Neuro-2A cells also reduced mRNA levels of caspases−3 and −7 and those of the pro-apoptotic molecule Bax; by contrast, hexarelin treatment increased anti-apoptotic Bcl-2 mRNA levels. Hexarelin also reduced MAPKs phosphorylation induced by H 2 O 2 and concurrently increased p-Akt protein expression. In conclusion, our results identify several neuroprotective and anti-apoptotic effects of hexarelin. These properties suggest that further investigation of hexarelin as a neuroprotective agent in an investigational and therapeutic context are merited." @default.
• W3102011969 created "2020-11-23" @default.
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• W3102011969 date "2020-11-16" @default.
• W3102011969 modified "2023-09-23" @default.
• W3102011969 title "Hexarelin exerts neuroprotective and antioxidant effects against hydrogen peroxide-induced toxicity through the modulation of MAPK and PI3K/Akt patways in Neuro-2A cells" @default.
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• W3102011969 doi "https://doi.org/10.1101/2020.11.16.384321" @default.
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