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• W3102016293 abstract "ABSTRACT Signal transduction pathways are intricately fine-tuned to accomplish diverse biological processes. An example is the conserved Ras/mitogen-activated-protein-kinase (MAPK) pathway, which exhibits context-dependent signaling output dynamics and regulation. Here, by altering codon usage as a novel platform to control signaling output, we screened the Drosophila genome for modifiers specific to either weak or strong Ras-driven eye phenotypes. We mapped the underlying gene from one modifier to the ribosomal gene RpS21 . RpS21 preferentially influences weak Ras/MAPK signaling outputs, and negatively regulates Ras/MAPK in multiple cell/tissue and signaling settings. In turn, MAPK signaling may regulate its own negative feedback by promoting RpS21 expression. These data show that codon usage manipulation can identify output-specific signaling regulators, and identify RpS21 as an in vivo Ras/MAPK phenotypic regulator." @default.
• W3102016293 created "2020-11-23" @default.
• W3102016293 creator A5013104381 @default.
• W3102016293 creator A5018521257 @default.
• W3102016293 creator A5029766234 @default.
• W3102016293 creator A5045916438 @default.
• W3102016293 creator A5058785226 @default.
• W3102016293 creator A5062464654 @default.
• W3102016293 creator A5080774278 @default.
• W3102016293 creator A5087099776 @default.
• W3102016293 date "2019-05-26" @default.
• W3102016293 modified "2023-09-26" @default.
• W3102016293 title "Exploiting codon usage identifies RpS21 as an<i>in vivo</i>signal strength-dependent Ras/MAPK regulator" @default.
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