Matches in SemOpenAlex for { <https://semopenalex.org/work/W3102041272> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3102041272 endingPage "2636" @default.
- W3102041272 startingPage "2628" @default.
- W3102041272 abstract "EPDR1 is widely expressed in cancer, especially colorectal cancer. However, the biologic function of EPDR1 in breast cancer is uncertain.The expression profile of EPDR1 was assessed by Gene Expression Profiling Interactive Analysis (GEPIA; gepia.cancer-pku.cn). We constructed EPDR1-overexpressing (EPDR1-Ov) plasmids that were transfected into breast cancer cells (MCF-7 and MDA-MB-453) to examine the EPDR1 effect on their malignant behavior. The EPDR1 overexpression and the critical components of the P53 signaling pathway were determined by western blot or RT-PCR. Cell proliferation, colony formation, invasive capacity, and cell apoptotic proportions were examined after transfection.mRNA expression of EPDR1 was significantly lessened in breast cancer tissues when compared to the adjacent normal tissues by data analysis from GEPIA. There was an impairment in proliferative ability, viability, invasion, and anti-apoptotic effect in EPDR1 overexpressed breast cancer cells. Mechanistic studies showed that EPDR1 overexpression increased the p53, p21 and Bcl-2 expression while inhibiting Bax expression.EPDR1 inhibited malignant behaviors and promoted apoptosis in breast cancer cells by activation of the p53 signaling pathway." @default.
- W3102041272 created "2020-11-23" @default.
- W3102041272 creator A5023776809 @default.
- W3102041272 creator A5071705086 @default.
- W3102041272 creator A5085285741 @default.
- W3102041272 date "2020-01-01" @default.
- W3102041272 modified "2023-09-30" @default.
- W3102041272 title "Overexpression of EPDR1 has an antitumorigenic effect on breast cancer in vitro." @default.
- W3102041272 cites W1983006882 @default.
- W3102041272 cites W1987941191 @default.
- W3102041272 cites W2046483028 @default.
- W3102041272 cites W2088803854 @default.
- W3102041272 cites W2089545133 @default.
- W3102041272 cites W2093229661 @default.
- W3102041272 cites W2108222684 @default.
- W3102041272 cites W2129141930 @default.
- W3102041272 cites W2131604549 @default.
- W3102041272 cites W2139210909 @default.
- W3102041272 cites W2210624024 @default.
- W3102041272 cites W2345833830 @default.
- W3102041272 cites W2545094884 @default.
- W3102041272 cites W2770097243 @default.
- W3102041272 cites W2792951836 @default.
- W3102041272 cites W2892660983 @default.
- W3102041272 cites W2897420802 @default.
- W3102041272 cites W2943875396 @default.
- W3102041272 cites W2999417355 @default.
- W3102041272 cites W3009853416 @default.
- W3102041272 cites W3010122169 @default.
- W3102041272 cites W3010206546 @default.
- W3102041272 cites W4241886935 @default.
- W3102041272 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7642719" @default.
- W3102041272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33165408" @default.
- W3102041272 hasPublicationYear "2020" @default.
- W3102041272 type Work @default.
- W3102041272 sameAs 3102041272 @default.
- W3102041272 citedByCount "5" @default.
- W3102041272 countsByYear W31020412722021 @default.
- W3102041272 countsByYear W31020412722022 @default.
- W3102041272 crossrefType "journal-article" @default.
- W3102041272 hasAuthorship W3102041272A5023776809 @default.
- W3102041272 hasAuthorship W3102041272A5071705086 @default.
- W3102041272 hasAuthorship W3102041272A5085285741 @default.
- W3102041272 hasConcept C104317684 @default.
- W3102041272 hasConcept C121608353 @default.
- W3102041272 hasConcept C150194340 @default.
- W3102041272 hasConcept C18431079 @default.
- W3102041272 hasConcept C190283241 @default.
- W3102041272 hasConcept C2776415932 @default.
- W3102041272 hasConcept C502942594 @default.
- W3102041272 hasConcept C526805850 @default.
- W3102041272 hasConcept C530470458 @default.
- W3102041272 hasConcept C54009773 @default.
- W3102041272 hasConcept C54355233 @default.
- W3102041272 hasConcept C62112901 @default.
- W3102041272 hasConcept C62478195 @default.
- W3102041272 hasConcept C81885089 @default.
- W3102041272 hasConcept C86803240 @default.
- W3102041272 hasConcept C95444343 @default.
- W3102041272 hasConcept C96232424 @default.
- W3102041272 hasConceptScore W3102041272C104317684 @default.
- W3102041272 hasConceptScore W3102041272C121608353 @default.
- W3102041272 hasConceptScore W3102041272C150194340 @default.
- W3102041272 hasConceptScore W3102041272C18431079 @default.
- W3102041272 hasConceptScore W3102041272C190283241 @default.
- W3102041272 hasConceptScore W3102041272C2776415932 @default.
- W3102041272 hasConceptScore W3102041272C502942594 @default.
- W3102041272 hasConceptScore W3102041272C526805850 @default.
- W3102041272 hasConceptScore W3102041272C530470458 @default.
- W3102041272 hasConceptScore W3102041272C54009773 @default.
- W3102041272 hasConceptScore W3102041272C54355233 @default.
- W3102041272 hasConceptScore W3102041272C62112901 @default.
- W3102041272 hasConceptScore W3102041272C62478195 @default.
- W3102041272 hasConceptScore W3102041272C81885089 @default.
- W3102041272 hasConceptScore W3102041272C86803240 @default.
- W3102041272 hasConceptScore W3102041272C95444343 @default.
- W3102041272 hasConceptScore W3102041272C96232424 @default.
- W3102041272 hasIssue "10" @default.
- W3102041272 hasLocation W31020412721 @default.
- W3102041272 hasOpenAccess W3102041272 @default.
- W3102041272 hasPrimaryLocation W31020412721 @default.
- W3102041272 hasRelatedWork W123250343 @default.
- W3102041272 hasRelatedWork W1965368778 @default.
- W3102041272 hasRelatedWork W2345180005 @default.
- W3102041272 hasRelatedWork W2347764733 @default.
- W3102041272 hasRelatedWork W2370510973 @default.
- W3102041272 hasRelatedWork W2382560511 @default.
- W3102041272 hasRelatedWork W2386114527 @default.
- W3102041272 hasRelatedWork W2586100275 @default.
- W3102041272 hasRelatedWork W3031235810 @default.
- W3102041272 hasRelatedWork W3040237278 @default.
- W3102041272 hasVolume "13" @default.
- W3102041272 isParatext "false" @default.
- W3102041272 isRetracted "false" @default.
- W3102041272 magId "3102041272" @default.
- W3102041272 workType "article" @default.