Matches in SemOpenAlex for { <https://semopenalex.org/work/W3102042370> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W3102042370 endingPage "41" @default.
- W3102042370 startingPage "34" @default.
- W3102042370 abstract "To study the effect of MDR1 and CYP3A5 gene polymorphisms on the outcomes of imatinib treatment in patients with chronic myeloid leukemia (CML).A total of 100 patients with CML treated with imatinib were enrolled in this study, including 50 patients with cytogenetic relapse (study group) and 50 without cytogenetic relapse (control group) during the follow-up for 45 months. For all the patients, single nucleotide polymorphisms (SNPs) of C1236T, C3435T, and G2677T/A loci in the MDR1 gene and A6986G locus in CYP3A5 gene were genotyped and the trough levels of imatinib was measured using LC-MS/MS. The relationship between SNPs of the loci and the risk of cytogenetic relapse were analyzed.The risk of cytogenetic recurrence was significantly higher in patients with CC genotypes of MDR1-C1236T and MDR1-C3435T than in those with CT + TT genotypes (P < 0.05). The median survival time of the patients with TT genotypes of MDR1-C3435T and MDR1-C1236T was significantly higher than that of patients with CC genotypes and CT genotypes (P < 0.05). The incidences of hematologic toxicity and neutropenia were significantly higher in patients with cytogenetic relapse than in those without cytogenetic relapse (P < 0.05). MDR1-C3435T genotype and imatinib concentration were independent predictors of cytogenetic relapse of CML.The risk of cytogenetic relapse of CML was significantly affected by SNPs of C1236T and C3435T loci of MDR1 gene and blood imatinib concentration. MDR1-C3435T genotype can be used as a potential biomarker for predicting cytogenetic relapse in CML patients." @default.
- W3102042370 created "2020-11-23" @default.
- W3102042370 creator A5010093557 @default.
- W3102042370 creator A5032881826 @default.
- W3102042370 creator A5042063399 @default.
- W3102042370 date "2018-01-30" @default.
- W3102042370 modified "2023-09-26" @default.
- W3102042370 title "[Effect of MDR1 and CYP3A5 gene polymorphisms on outcomes of patients receiving imatinib treatment for chronic myeloid leukemia]." @default.
- W3102042370 cites W1507788646 @default.
- W3102042370 cites W1924236513 @default.
- W3102042370 cites W1970229217 @default.
- W3102042370 cites W1971113538 @default.
- W3102042370 cites W1978350956 @default.
- W3102042370 cites W1983555178 @default.
- W3102042370 cites W1991593432 @default.
- W3102042370 cites W1997397403 @default.
- W3102042370 cites W1998142988 @default.
- W3102042370 cites W1998220517 @default.
- W3102042370 cites W2011979221 @default.
- W3102042370 cites W2014933948 @default.
- W3102042370 cites W2015788322 @default.
- W3102042370 cites W2027504487 @default.
- W3102042370 cites W2034335509 @default.
- W3102042370 cites W2050646947 @default.
- W3102042370 cites W2052406081 @default.
- W3102042370 cites W2055515709 @default.
- W3102042370 cites W2061005005 @default.
- W3102042370 cites W2066731188 @default.
- W3102042370 cites W2105214030 @default.
- W3102042370 cites W2105902511 @default.
- W3102042370 cites W2130097555 @default.
- W3102042370 cites W2141106022 @default.
- W3102042370 cites W2143464932 @default.
- W3102042370 cites W2148857879 @default.
- W3102042370 cites W2158884958 @default.
- W3102042370 cites W2260921597 @default.
- W3102042370 cites W2273178174 @default.
- W3102042370 cites W2343511371 @default.
- W3102042370 cites W2343861412 @default.
- W3102042370 cites W2605328512 @default.
- W3102042370 doi "https://doi.org/10.3969/j.issn.1673-4254.2018.01.06" @default.
- W3102042370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6765618" @default.
- W3102042370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33177018" @default.
- W3102042370 hasPublicationYear "2018" @default.
- W3102042370 type Work @default.
- W3102042370 sameAs 3102042370 @default.
- W3102042370 citedByCount "0" @default.
- W3102042370 crossrefType "journal-article" @default.
- W3102042370 hasAuthorship W3102042370A5010093557 @default.
- W3102042370 hasAuthorship W3102042370A5032881826 @default.
- W3102042370 hasAuthorship W3102042370A5042063399 @default.
- W3102042370 hasConcept C104317684 @default.
- W3102042370 hasConcept C126322002 @default.
- W3102042370 hasConcept C135763542 @default.
- W3102042370 hasConcept C143998085 @default.
- W3102042370 hasConcept C153209595 @default.
- W3102042370 hasConcept C2777583451 @default.
- W3102042370 hasConcept C2778729363 @default.
- W3102042370 hasConcept C54355233 @default.
- W3102042370 hasConcept C71924100 @default.
- W3102042370 hasConcept C86803240 @default.
- W3102042370 hasConcept C90924648 @default.
- W3102042370 hasConcept C92137452 @default.
- W3102042370 hasConceptScore W3102042370C104317684 @default.
- W3102042370 hasConceptScore W3102042370C126322002 @default.
- W3102042370 hasConceptScore W3102042370C135763542 @default.
- W3102042370 hasConceptScore W3102042370C143998085 @default.
- W3102042370 hasConceptScore W3102042370C153209595 @default.
- W3102042370 hasConceptScore W3102042370C2777583451 @default.
- W3102042370 hasConceptScore W3102042370C2778729363 @default.
- W3102042370 hasConceptScore W3102042370C54355233 @default.
- W3102042370 hasConceptScore W3102042370C71924100 @default.
- W3102042370 hasConceptScore W3102042370C86803240 @default.
- W3102042370 hasConceptScore W3102042370C90924648 @default.
- W3102042370 hasConceptScore W3102042370C92137452 @default.
- W3102042370 hasIssue "1" @default.
- W3102042370 hasLocation W31020423701 @default.
- W3102042370 hasOpenAccess W3102042370 @default.
- W3102042370 hasPrimaryLocation W31020423701 @default.
- W3102042370 hasRelatedWork W16693249 @default.
- W3102042370 hasRelatedWork W1964081644 @default.
- W3102042370 hasRelatedWork W2075325761 @default.
- W3102042370 hasRelatedWork W2122443624 @default.
- W3102042370 hasRelatedWork W2131584305 @default.
- W3102042370 hasRelatedWork W2140730018 @default.
- W3102042370 hasRelatedWork W2189624004 @default.
- W3102042370 hasRelatedWork W2581036173 @default.
- W3102042370 hasRelatedWork W2785477024 @default.
- W3102042370 hasRelatedWork W4212967416 @default.
- W3102042370 hasVolume "38" @default.
- W3102042370 isParatext "false" @default.
- W3102042370 isRetracted "false" @default.
- W3102042370 magId "3102042370" @default.
- W3102042370 workType "article" @default.