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• W3102065348 abstract "Abstract The yeast Candida albicans is a commensal of humans and opportunistic pathogen. Given that C. albicans transitions between benign commensal and harmful pathogen, studying the factors that contribute to virulence is often challenging and frequently depends on many contexts including host immune status and pathogen genetic background. However, ploidy has often been overlooked when studying C. albicans virulence. Given that polyploid C. albicans have been identified in clinical settings and that other fungal pathogens display extensive ploidy variation, assessing how ploidy impacts virulence has important clinical relevance. Here, we utilize the nematode C. elegans as a mini-host system to study how pathogen ploidy and genetic background impact fungal infection in healthy and immunocompromised host contexts. In addition to reducing overall survival of nematode hosts, Candida infection also results in negatively impacts host reproduction and allows us to survey lethal and non-lethal virulence phenotypes. While we do not detect any global differences in virulence between diploid and tetraploid C. albicans, there is a significant interaction between ploidy and C. albicans genetic background in both healthy and immunocompromised host contexts. Furthermore, in specific C. albicans genetic backgrounds tetraploids are more virulent than their diploid counterpart whereas other genetic backgrounds the diploid is more virulent. Importantly, these genetic background dependent ploidy patterns are consistent across lethal and non-lethal virulence phenotypes and host immune status." @default.
• W3102065348 created "2020-11-23" @default.
• W3102065348 creator A5000374351 @default.
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• W3102065348 date "2019-06-15" @default.
• W3102065348 modified "2023-09-26" @default.
• W3102065348 title "Fungal virulence depends on interactions between pathogen ploidy and genetic background in healthy and immunocompromised hosts" @default.
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