FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3102157031> ?p ?o ?g. }

• W3102157031 endingPage "e001662" @default.
• W3102157031 startingPage "e001662" @default.
• W3102157031 abstract "Background There remains a significant need to eliminate the risk of recurrence of resected cancers. Cancer vaccines are well tolerated and activate tumor-specific immune effectors and lead to long-term survival in some patients. We hypothesized that vaccination with alphaviral replicon particles encoding tumor associated antigens would generate clinically significant antitumor immunity to enable prolonged overall survival (OS) in patients with both metastatic and resected cancer. Methods OS was monitored for patients with stage IV cancer treated in a phase I study of virus-like replicon particle (VRP)-carcinoembryonic antigen (CEA), an alphaviral replicon particle encoding a modified CEA. An expansion cohort of patients (n=12) with resected stage III colorectal cancer who had completed their standard postoperative adjuvant chemotherapy was administered VRP-CEA every 3 weeks for a total of 4 immunizations. OS and relapse-free survival (RFS) were determined, as well as preimmunization and postimmunization cellular and humoral immunity. Results Among the patients with stage IV cancer, median follow-up was 10.9 years and 5-year survival was 17%, (95% CI 6% to 33%). Among the patients with stage III cancer, the 5-year RFS was 75%, (95%CI 40% to 91%); no deaths were observed. At a median follow-up of 5.8 years (range: 3.9–7.0 years) all patients were still alive. All patients demonstrated CEA-specific humoral immunity. Patients with stage III cancer had an increase in CD8 +T EM (in 10/12) and decrease in FOXP3 +Tregs (in 10/12) following vaccination. Further, CEA-specific, IFNγ-producing CD8+granzyme B+T CM cells were increased. Conclusions VRP-CEA induces antigen-specific effector T cells while decreasing Tregs, suggesting favorable immune modulation. Long-term survivors were identified in both cohorts, suggesting the OS may be prolonged." @default.
• W3102157031 created "2020-11-23" @default.
• W3102157031 creator A5012804507 @default.
• W3102157031 creator A5014771958 @default.
• W3102157031 creator A5020078440 @default.
• W3102157031 creator A5023821870 @default.
• W3102157031 creator A5039484460 @default.
• W3102157031 creator A5045134210 @default.
• W3102157031 creator A5053154937 @default.
• W3102157031 creator A5059968573 @default.
• W3102157031 creator A5070264002 @default.
• W3102157031 creator A5073130519 @default.
• W3102157031 creator A5074731037 @default.
• W3102157031 creator A5077597600 @default.
• W3102157031 date "2020-11-01" @default.
• W3102157031 modified "2023-10-17" @default.
• W3102157031 title "Long-term survival of patients with stage III colon cancer treated with VRP-CEA(6D), an alphavirus vector that increases the CD8+ effector memory T cell to Treg ratio" @default.
• W3102157031 cites W181099857 @default.
• W3102157031 cites W1960485012 @default.
• W3102157031 cites W1965827638 @default.
• W3102157031 cites W1993835819 @default.
• W3102157031 cites W2024223400 @default.
• W3102157031 cites W2052546898 @default.
• W3102157031 cites W2096151993 @default.
• W3102157031 cites W2101412338 @default.
• W3102157031 cites W2114104545 @default.
• W3102157031 cites W2130116522 @default.
• W3102157031 cites W2130261432 @default.
• W3102157031 cites W2138839690 @default.
• W3102157031 cites W2146512944 @default.
• W3102157031 cites W2290269515 @default.
• W3102157031 cites W2511635014 @default.
• W3102157031 cites W2612538354 @default.
• W3102157031 cites W2712978371 @default.
• W3102157031 cites W2766051916 @default.
• W3102157031 cites W2795004907 @default.
• W3102157031 cites W2889651900 @default.
• W3102157031 cites W2894796660 @default.
• W3102157031 cites W2911100812 @default.
• W3102157031 cites W2951108120 @default.
• W3102157031 cites W2951388901 @default.
• W3102157031 cites W2952775948 @default.
• W3102157031 cites W2965445854 @default.
• W3102157031 cites W2990310466 @default.
• W3102157031 cites W3029756234 @default.
• W3102157031 cites W3036941781 @default.
• W3102157031 cites W3083442449 @default.
• W3102157031 doi "https://doi.org/10.1136/jitc-2020-001662" @default.
• W3102157031 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7661359" @default.
• W3102157031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33177177" @default.
• W3102157031 hasPublicationYear "2020" @default.
• W3102157031 type Work @default.
• W3102157031 sameAs 3102157031 @default.
• W3102157031 citedByCount "24" @default.
• W3102157031 countsByYear W31021570312021 @default.
• W3102157031 countsByYear W31021570312022 @default.
• W3102157031 countsByYear W31021570312023 @default.
• W3102157031 crossrefType "journal-article" @default.
• W3102157031 hasAuthorship W3102157031A5012804507 @default.
• W3102157031 hasAuthorship W3102157031A5014771958 @default.
• W3102157031 hasAuthorship W3102157031A5020078440 @default.
• W3102157031 hasAuthorship W3102157031A5023821870 @default.
• W3102157031 hasAuthorship W3102157031A5039484460 @default.
• W3102157031 hasAuthorship W3102157031A5045134210 @default.
• W3102157031 hasAuthorship W3102157031A5053154937 @default.
• W3102157031 hasAuthorship W3102157031A5059968573 @default.
• W3102157031 hasAuthorship W3102157031A5070264002 @default.
• W3102157031 hasAuthorship W3102157031A5073130519 @default.
• W3102157031 hasAuthorship W3102157031A5074731037 @default.
• W3102157031 hasAuthorship W3102157031A5077597600 @default.
• W3102157031 hasBestOaLocation W31021570311 @default.
• W3102157031 hasConcept C121608353 @default.
• W3102157031 hasConcept C126322002 @default.
• W3102157031 hasConcept C143998085 @default.
• W3102157031 hasConcept C146357865 @default.
• W3102157031 hasConcept C151730666 @default.
• W3102157031 hasConcept C167672396 @default.
• W3102157031 hasConcept C203014093 @default.
• W3102157031 hasConcept C22070199 @default.
• W3102157031 hasConcept C2777387746 @default.
• W3102157031 hasConcept C2777863537 @default.
• W3102157031 hasConcept C2778220009 @default.
• W3102157031 hasConcept C526805850 @default.
• W3102157031 hasConcept C71924100 @default.
• W3102157031 hasConcept C72563966 @default.
• W3102157031 hasConcept C86803240 @default.
• W3102157031 hasConcept C8891405 @default.
• W3102157031 hasConcept C90924648 @default.
• W3102157031 hasConceptScore W3102157031C121608353 @default.
• W3102157031 hasConceptScore W3102157031C126322002 @default.
• W3102157031 hasConceptScore W3102157031C143998085 @default.
• W3102157031 hasConceptScore W3102157031C146357865 @default.
• W3102157031 hasConceptScore W3102157031C151730666 @default.
• W3102157031 hasConceptScore W3102157031C167672396 @default.
• W3102157031 hasConceptScore W3102157031C203014093 @default.
• W3102157031 hasConceptScore W3102157031C22070199 @default.
• W3102157031 hasConceptScore W3102157031C2777387746 @default.
• W3102157031 hasConceptScore W3102157031C2777863537 @default.

• next