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• W3102332210 abstract "Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8+ cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT that correlate with successful responses have not been well characterized. Here, we studied murine tumor models with dichotomous responses to ICT. We tracked tumor antigen-specific CTL frequencies and phenotype before and after ICT in responding and non-responding animals. Tumor antigen-specific CTLs increased within tumor and draining lymph nodes after ICT, and exhibited an effector memory-like phenotype, expressing IL-7R (CD127), KLRG1, T-bet, and granzyme B. Responding tumors exhibited higher infiltration of effector memory tumor antigen-specific CTLs, but lower frequencies of regulatory T cells compared to non-responders. Tumor antigen-specific CTLs persisted in responding animals and formed memory responses against tumor antigens. Our results suggest that increased effector memory tumor antigen-specific CTLs, in the presence of reduced immunosuppression within tumors is part of a successful ICT response. Temporal and nuanced analysis of T cell subsets provides a potential new source of immune based biomarkers for response to ICT." @default.
• W3102332210 created "2020-11-23" @default.
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• W3102332210 date "2020-11-12" @default.
• W3102332210 modified "2023-10-15" @default.
• W3102332210 title "Tumor Infiltrating Effector Memory Antigen-Specific CD8+ T Cells Predict Response to Immune Checkpoint Therapy" @default.
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• W3102332210 doi "https://doi.org/10.3389/fimmu.2020.584423" @default.
• W3102332210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7688517" @default.
• W3102332210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33262762" @default.
• W3102332210 hasPublicationYear "2020" @default.
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