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- W3102379572 abstract "An investigation of CA1 pyramidal model is an important issue for applications, which is intimately related to the composition of ions in the extracellular environment and external stimulation. In this paper, it is demonstrated that the effects of different electrophysiological parameters such as muscarinic-sensitive potassium current activation variable and sustained sodium current inactivation variable on the firing sequence of model by numerical simulations. Furthermore, the paper also discusses that the temperature affects the firing of the CA1 model from direct current (DC) and alternating current (AC) stimuli. It is found that the model exhibits excellent spiking and bursting patterns, even chaotic patterns occur. Meanwhile, generalized mixed oscillations emerge in the model. Additionally, the firing modes are depicted by providing the response curve (RC), inter-spike interval curve (ISI), phase diagram curve (PDC) and the number of spikes per burst curve (NC). Mathematically, the paper elaborates the results which are presented to obtain two lower dimensional subsystems, which govern the fast and slow dynamics for giving insight into the dynamic behaviors of the full 5D system based on the geometric singular perturbation theory (GSPT). Particularly, we analyse the phase diagrams of the CA1 model to understand the properties better. The present results may contribute to further understand the information processing of the CA1 pyramidal neurons." @default.
- W3102379572 created "2020-11-23" @default.
- W3102379572 creator A5049920351 @default.
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- W3102379572 date "2020-11-17" @default.
- W3102379572 modified "2023-09-25" @default.
- W3102379572 title "Firing patterns of the CA1 pyramidal neuron with geometric singular perturbation: a model study" @default.
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- W3102379572 doi "https://doi.org/10.1142/s0217979220503166" @default.
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