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• W3102426328 startingPage "20140982" @default.
• W3102426328 abstract "How multicellular life forms evolved from unicellular ones constitutes a major problem in our understanding of the evolution of our biosphere. A recent set of experiments involving yeast cell populations have shown that selection for faster sedimenting cells leads to the appearance of stable aggregates of cells that are able to split into smaller clusters. It was suggested that the observed evolutionary patterns could be the result of evolved programmes affecting cell death. Here, we show, using a simple model of cell–cell interactions and evolving adhesion rates, that the observed patterns in cluster size and localized mortality can be easily interpreted in terms of waste accumulation and toxicity-driven apoptosis. This simple mechanism would have played a key role in the early evolution of multicellular life forms based on both aggregative and clonal development. The potential extensions of this work and its implications for natural and synthetic multicellularity are discussed." @default.
• W3102426328 created "2020-11-23" @default.
• W3102426328 creator A5046878011 @default.
• W3102426328 creator A5089868966 @default.
• W3102426328 date "2015-01-01" @default.
• W3102426328 modified "2023-09-27" @default.
• W3102426328 title "Emergence of multicellularity in a model of cell growth, death and aggregation under size-dependent selection" @default.
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• W3102426328 doi "https://doi.org/10.1098/rsif.2014.0982" @default.
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