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- W310244677 abstract "Publisher Summary This chapter discusses the critical role of cyclic adenosine monophosphate (AMP) in the regulation of the metabolism of higher organisms and its action as a second messenger in hormone action that was well established before cyclic AMP was even detected in Escherichia coli . The first clue to the possible role of cyclic AMP in mediating catabolite repression was provided by the studies of Makman and Sutherland. Cyclic AMP levels are high in cells growing on glycerol in which the differential rate of synthesis of inducible enzymes is high. The conclusion that cyclic AMP acts at a transcriptional level is supported by other studies on the nature of the genetic site at which cyclic AMP acts. The lac promoter mutants are not the only class of mutants unresponsive to cyclic AMP. Transcription has also been studied in crude cell-free extracts, and cyclic AMP has been found to increase lac mRNA synthesis. In E. coli cyclic AMP is required for the synthesis of inducible enzymes." @default.
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- W310244677 date "1971-01-01" @default.
- W310244677 modified "2023-09-27" @default.
- W310244677 title "Regulation of Gene Expression in Escherichia coli by Cyclic AMP" @default.
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- W310244677 doi "https://doi.org/10.1016/b978-0-12-571127-2.50034-1" @default.
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