FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3102725912> ?p ?o ?g. }

• W3102725912 abstract "Two cosegregating single-nucleotide polymorphisms (SNPs) in human TLR4, an A896G transition at SNP rs4986790 (D299G) and a C1196T transition at SNP rs4986791 (T399I), have been associated with LPS hyporesponsiveness and differential susceptibility to many infectious or inflammatory diseases. However, many studies failed to confirm these associations, and transfection experiments resulted in conflicting conclusions about the impact of these SNPs on TLR4 signaling. Using advanced protein modeling from crystallographic data of human and murine TLR4, we identified homologous substitutions of these SNPs in murine Tlr4, engineered a knock-in strain expressing the D298G and N397I TLR4 SNPs homozygously, and characterized in vivo and in vitro responses to TLR4 ligands and infections in which TLR4 is implicated. Our data provide new insights into cellular and molecular mechanisms by which these SNPs decrease the TLR4 signaling efficiency and offer an experimental approach to confirm or refute human data possibly confounded by variables unrelated to the direct effects of the SNPs on TLR4 functionality." @default.
• W3102725912 created "2020-11-23" @default.
• W3102725912 creator A5001609849 @default.
• W3102725912 creator A5003951001 @default.
• W3102725912 creator A5010314005 @default.
• W3102725912 creator A5015698726 @default.
• W3102725912 creator A5018165248 @default.
• W3102725912 creator A5037049593 @default.
• W3102725912 creator A5041046556 @default.
• W3102725912 creator A5062357638 @default.
• W3102725912 creator A5064952582 @default.
• W3102725912 creator A5069509653 @default.
• W3102725912 creator A5071156187 @default.
• W3102725912 creator A5071967253 @default.
• W3102725912 creator A5076332922 @default.
• W3102725912 creator A5089505596 @default.
• W3102725912 creator A5090780152 @default.
• W3102725912 date "2020-11-20" @default.
• W3102725912 modified "2023-10-17" @default.
• W3102725912 title "A mouse model of human TLR4 D299G/T399I SNPs reveals mechanisms of altered LPS and pathogen responses" @default.
• W3102725912 cites W1480678645 @default.
• W3102725912 cites W1499978168 @default.
• W3102725912 cites W1520365933 @default.
• W3102725912 cites W1528847947 @default.
• W3102725912 cites W1534378060 @default.
• W3102725912 cites W1536965618 @default.
• W3102725912 cites W1550446004 @default.
• W3102725912 cites W1560892967 @default.
• W3102725912 cites W1561771836 @default.
• W3102725912 cites W1577886890 @default.
• W3102725912 cites W1584178906 @default.
• W3102725912 cites W1591790122 @default.
• W3102725912 cites W1597676074 @default.
• W3102725912 cites W1605072661 @default.
• W3102725912 cites W1606609113 @default.
• W3102725912 cites W1803102843 @default.
• W3102725912 cites W1824737122 @default.
• W3102725912 cites W1872259428 @default.
• W3102725912 cites W1897919101 @default.
• W3102725912 cites W1920324450 @default.
• W3102725912 cites W1971824402 @default.
• W3102725912 cites W1981839489 @default.
• W3102725912 cites W1984404627 @default.
• W3102725912 cites W1986266598 @default.
• W3102725912 cites W1990127366 @default.
• W3102725912 cites W1999286245 @default.
• W3102725912 cites W2007701914 @default.
• W3102725912 cites W2008826892 @default.
• W3102725912 cites W2025648442 @default.
• W3102725912 cites W2028627944 @default.
• W3102725912 cites W2028806189 @default.
• W3102725912 cites W2031889218 @default.
• W3102725912 cites W2037894162 @default.
• W3102725912 cites W2038073973 @default.
• W3102725912 cites W2038486513 @default.
• W3102725912 cites W2041361746 @default.
• W3102725912 cites W2050650519 @default.
• W3102725912 cites W2073410163 @default.
• W3102725912 cites W2082179952 @default.
• W3102725912 cites W2087867048 @default.
• W3102725912 cites W2106910647 @default.
• W3102725912 cites W2107277218 @default.
• W3102725912 cites W2111428445 @default.
• W3102725912 cites W2112223832 @default.
• W3102725912 cites W2119121947 @default.
• W3102725912 cites W2124026197 @default.
• W3102725912 cites W2125537221 @default.
• W3102725912 cites W2125575826 @default.
• W3102725912 cites W2127322768 @default.
• W3102725912 cites W2127934565 @default.
• W3102725912 cites W2128364938 @default.
• W3102725912 cites W2129319296 @default.
• W3102725912 cites W2130655121 @default.
• W3102725912 cites W2132413368 @default.
• W3102725912 cites W2132812582 @default.
• W3102725912 cites W2134814935 @default.
• W3102725912 cites W2144136875 @default.
• W3102725912 cites W2151038767 @default.
• W3102725912 cites W2151652295 @default.
• W3102725912 cites W2151946220 @default.
• W3102725912 cites W2152322635 @default.
• W3102725912 cites W2152994693 @default.
• W3102725912 cites W2159560463 @default.
• W3102725912 cites W2169026862 @default.
• W3102725912 cites W2192080449 @default.
• W3102725912 cites W2257036949 @default.
• W3102725912 cites W2443409987 @default.
• W3102725912 cites W2562449006 @default.
• W3102725912 cites W2571748583 @default.
• W3102725912 cites W2602846991 @default.
• W3102725912 cites W2606546819 @default.
• W3102725912 cites W2760978511 @default.
• W3102725912 cites W2767795362 @default.
• W3102725912 cites W2778840601 @default.
• W3102725912 cites W2784697675 @default.
• W3102725912 cites W2786007302 @default.
• W3102725912 cites W2803253620 @default.
• W3102725912 cites W2891712574 @default.
• W3102725912 cites W2898478236 @default.
• W3102725912 cites W2944795429 @default.

• next